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Jang, Hyon Chol

Jang, Hyon Chol, Ph.D. (adjunct professor)
Faculty Appointment
(title, department)

Assistant Professor, Department of Cancer Biomedical Science, NCC-GCSP
Senior Scientist, National Cancer Center (2013~present)
Area of Expertise
Cancer Stemness
Contact no
Previous Appointment(s) Held
Senior Scientist, National Cancer Center (2013~present)
Associate editor, Experimental & Molecular Medicine (2014~present)
Researcher, Seoul National University Medical Research Center (2012~2013)
Postdoctoral Associate/Fellow : Seoul National University College of Medicine (2006~2012)
Educational Background
Ph.D. (2006) Molecular & Cellular Biology, Seoul National University
M.S. (2000) Bioorganic Chemistry, Seoul National University
B.S. (1998) Chemistry, Seoul National University
Research Interests (Please place in paragraph form)
Dr. Jang’s research focuses on understanding “stemness” of cancer cells to elucidate cancer cells of origin and main cause of cancer relapse after standard therapy.
International Collaboration
2019 SCI-E False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases: PLOS ONE. 14(9):e0222535~e0222535 (2.776)

2019 SCI-E FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer: CANCERS. 11(9):e1288~e1288 (6.162)

2018 SCI Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness: Experimental & molecular medicine. 50(1):137~137 (5.584)

2018 SCI-E AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells: CELL DEATH AND DISEASE. 9(10):972~972 (5.638)

2018 SCI OCT4 directly regulates stemness and extracellular matrix-related genes in human germ cell tumours: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 503(3):1980~1986 (2.559)

2018 SCI Cyclin-dependent kinase 1 activity coordinates the chromatin associated state of Oct4 during cell cycle in embryonic stem cells: Nucleic acids research. 46(13):6544~6560 (11.561)

2018 SCI Abundance of C-terminal binding protein isoform is a prerequisite for exit from pluripotency in mouse embryonic stem cells: FASEB journal. Online:Published (5.595)

2018 SCI-E FAM188B enhances cell survival via interaction with USP7, Cell Death and Disease: CELL DEATH AND DISEASE. 9:633~633 (5.638)

2017 SCI The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization: International Journal of Biological Macromolecules. 103:965~971 (3.671)

2016 SCI Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity.: Experimental and Molecular Medicine. 48(12):e277~e277 (5.164)

2016 SCI Aldehyde dehydrogenase is used by cancer cells for energy metabolism: Experimental & Molecular Medicine. 48(11):e272~e272 (5.164)

2016 SCI Psat1-Dependent Fluctuations in a-Ketoglutarate Affect the Timing of ESC Differentiation: Cell Metabolism. 24(3):494~501 (17.303)

2016 SCI-E Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion: Oncotarget. 7(31):49397~49410 (5.008)

2016 SCI Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells: eLIFE. 5:1~21 (8.303)

2015 기타 Recombinant Human Laforin Expressed in Insect Cells: Expression, Purification, and Biochemical Characterizations: Journal of the Korean Chemical Society. 59:466~470 (0)

2015 SCI Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency: Stem Cells. 33:2699~2711 (6.523)

2015 SCI Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active ESC Genes During Exit From Pluripotency: Stem cells. 33(8):2442~2455 (6.523)

2015 SCI AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage: Nucleic acids research. 43(9):4505~4516 (9.112)

2015 SCI Pontin Functions as an Essential Coactivator for Oct4-Dependent LincRNA expression in Mouse Embryonic Stem Cells: Nature communications [electronic resource]. 6:6810~6810 (11.47)

2015 SCI-E Metabolism in embryonic and cancer stemness: Archives of pharmacal research. 38(3):381~388 (2.046)

2015 SCI ATP-citrate lyase regulates cellular senescence via an AMPK-and p53-dependent pathway.: The FEBS Journal. 282(2):361~371 (4.001)

2014 SCI Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation: Nucleic Acids Research. 42(1):224~234 (8.808)

2013 SCI Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.: Cell Death & Disease. 4:e583~e583 (6.044)

2013 SCI Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress: Nucleic Acids Res. 41(4):2180~2190 (8.278)

2012 SCI O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network: Cell Stem Cell. 11:62~74 (25.421)

2011 SCI Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis.: Biochem Biophys Res Commun.. 407:541~547 (2.484)

2010 SCI Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors.: Biochem Biophys Res Commun.. 401:327~332 (2.484)

2009 SCI Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin: Exp Mol Med.. 41:471~477 (2.481)

2009 SCI Cabin1 restrains p53 activity on chromatin: Nat Struct Mol Biol.. :910~915 (12.712)

2009 SCI Ferritin binds and activates p53 under oxidative stress: Biochem Biophys Res Commun. 389:399~404 (2.484)

2007 SCI A new calcineurin inhibition domain in Cabin1: Biochem Biophys Res Commun.. 359:129~135 (2.855)

2007 SCI Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1: J Biol Chem.. 282:11172~11179 (5.808)

2007 SCI Hydrogen peroxide triggers the proteolytic cleavage and the inactivation of calcineurin: J Neurochem.. 100:1703~1712 (4.26)