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Hee Sun Cheong

Name
Cheong, Hee Sun, Ph.D. (adjunct professor)
Faculty Appointment
(title, department)

Assistant professor, Department of Cancer Biomedical Science , NCC-GCSP Senior Scientist, Comparative Biomedicine Research Branch, Division of Cancer Biology, National Cancer Center
Area of Expertise
Caner metabolism and autophagy
Contact no
+82-31-920-2272
E-mail
heesunch@ncc.re.kr
Previous Appointment(s) Held
Senior Scientist, National Cancer Center Korea (2014~Present)
Principal Research Scientist, CKD(ChongKeunDang) Research Institute, CKD pharmaceutical Corp., Yong-in, Korea(2013~2014)
Research Scholar, Memorial Sloan-Kettering Cancer Center, New York, USA (2011~2013)
Post-doctoral Fellow, University of Pennsylvania, Philadelphia, USA (2009~2011)
Research Scientist, Biotech Research Institute, LG Chemical Ltd, Korea (1995~2000)
Educational Background
Ph.D. Molecular and Cellular Biology,University of Michigan, Ann Arbor, USA (2008)
M.S.Biochemistry, Yonsei University, Korea (1994)
B.S. Biology, KyungHee University (1992)
Research Interests (Please place in paragraph form)
Dr. Cheong’s research focuses on investigation of regulatory mechanism of autophagy and its molecular connection to alterations in cancer metabolism. Metabolic stress derived from abnormal cancer cell proliferation leads to autophagy. Autophagy is a catabolic process leading to the degradation of cellular components through a lysosomal pathway. Understanding the context-dependent role of autophagy in cancer development remains a hot topic in oncology research and has profound implication for the design of cancer therapeutics.
International Collaboration
2017 SCI-E REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival: International Journal of Molecular Science. 18(9):E1866~E1866 (3.226)

2017 SCI Tandem-multimeric F3-gelonin fusion toxins for enhanced anti-cancer activity for prostate cancer treatment: International journal of Pharmaceutics. 524(1-2):101~110 (3.649)

2016 SCI Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity.: Experimental and Molecular Medicine. 48(12):e277~e277 (5.164)

2016 SCI Autophagy is required for PDAC glutamine metabolism: Scientific Reports. 6:37594~37594 (5.228)

2016 SCI Osterix represses adipogenesis by negatively regulating PPARγ transcriptional activity: Scientific Reports. 6:35655~35655 (5.228)

2016 SCI Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity: Pharmaceutical Research. 33(9):2218~2228 (3.26)

2016 SCI-E mTORC1 regulates nutrient access in Ras-mediated tumors.: Aging (Albany NY). 8:1165~1166 (3.979)

2016 SCI Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry: Archives of Pharmacal Research. 39:668~676 (2.49)

2016 SCI-E Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).: Autophagy. 12(1):1~222 (9.108)

2015 SCI-E Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras: Oncotarget. 6:40405~40417 (6.359)

2015 SCI mTORC1 maintains metabolic balance: Cell Research. 25(10):1085~1086 (12.413)

2015 SCI Yin Yang 1 is a multi-functional regulator of adipocyte differentiation in 3T3-L1 cells: Molecular and Cellular Endocrinology. 413:217~227 (4.405)

2015 SCI Src enhances osteogenic differentiation through phosphorylation of Osterix: Molecular and cellular endocrinology. 407:85~97 (4.405)

2015 SCI-E Integrating autophagy and metabolism in cancer: Archives of pharmacal research. 38(3):358~371 (2.046)

2015 SCI Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix: Molecular and cellular endocrinology. 400:32~40 (4.405)

2014 SCI-E Detection of Saccharomyces cerevisiae Atg13 by western blot: Autophagy. 10(3):514~517 (11.423)

2014 SCI-E Analysis of a lung defect in autophagy-deficient mouse strains: Autophagy. 10(1):45~56 (11.423)

2013 SCI Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110:E2875~E2884 (9.737)

2012 SCI-E Therapeutic targets in cancer cell metabolism and autophagy: NATURE BIOTECHNOLOGY. 30:671~678 (32.438)

2012 SCI-E Autophagy and ammonia: AUTOPHAGY. 8:122~123 (12.042)

2011 SCI Ammonia-induced autophagy is independent of ULK1/ULK2 kinases: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108:11121~11126 (9.681)

2008 SCI In vivo reconstitution of autophagy in Saccharomyces cerevisiae: JOURNAL OF CELL BIOLOGY. 182:703~713 (9.12)

2008 SCI-E Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiae: AUTOPHAGY. 4:724~726 (5.479)

2008 SCI The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle format: MOLECULAR BIOLOGY OF THE CELL. 19:668~681 (5.558)

2008 SCI-E BIOCHEMICAL METHODS TO MONITOR AUTOPHAGY-RELATED PROCESSES IN YEAST: Methods in Enzymology AUTOPHAGY: LOWER EUKARYOTES AND NON-MAMMALIAN SYSTEMS, PT A. 451:1~26 (2.372)

2005 SCI Atg17 regulates the magnitude of the autophagic response: MOLECULAR BIOLOGY OF THE CELL. 16:3438~3453 (6.52)

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