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Park, Byung Kiu, M.D., Ph.D.(adjunct professor)
Faculty Appointment
(title, department)
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Head, Center for Pediatric Oncology, National Cancer Center
Area of Expertise
Pediatric Oncology
Contact no
Previous Appointment(s) Held
Chief, Pediatric Oncology Branch, National Cancer Center
Head, Division of Translational & Clinical Research II, National Cancer Center
Chairman, Institutional Review Board, National Cancer Center
Professor, Gyeongsang National University, College of Medicine
Educational Background
1981 Seoul National University College of Medicine, M.D.
1990 Graduate School of Medicine, Seoul National University, Ph.D.
Research Interests (Please place in paragraph form)
Dr. Park, Byung Kiu earned his M.D. from Seoul National University, and completed residency training and fellowship in Pediatrics at Seoul National University Children’s Hospital. While holding a faculty position at Gyeongsang National University, he had worked as a postdoctoral fellow(1993-1996) in the National Cancer Institute(NCI) and the National Institute of Child Health and Human Development(NICHD), National Institutes of Health(NIH) in USA. His current research interests include the molecular mechanism of sarcoma progression and the discovery of target molecules as predictive and prognostic biomarkers, and clinical trials on childhood sarcomas.
International Collaboration
Member, Children’s Oncology Group(COG)
Member, International Society of Paediatric Oncology(SIOP)
Member, American Association for Cancer Research(AACR)
Member, American Society of Clinical Oncology(ASCO)
Member, Connective Tissue Oncology Society(CTOS)
2019 SCI Upregulation of transforming growth factor-beta type I receptor by interferon consensus sequence-binding protein in osteosarcoma cells: Biochimica et Biophysica Acta(BBA)-Molecular Cell Research. 1866(5):761~772 (4.651)

2019 SCI-E C/EBPβ Is a Transcriptional Regulator of Wee1 at the G₂/M Phase of the Cell Cycle.: CELLS. 8(2):E145~E145 (4.829)

2019 SCI-E Thromboembolism in children with cancer: a retrospective multicenter study in Korea: Journal of Thrombosis and Thrombolysis. Online:Published (2.62)

2018 SCI A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005-2014: A Comparison with United States Data.: CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION. 28(2):409~416 (4.554)

2018 SCI-E Second malignant neoplasms after childhood cancer: A nationwide population-based study in Korea: PLOS ONE. 13(11):e0207243~e0207243 (2.766)

2018 SCI-E School performance of childhood cancer survivors in Korea: a multi-institutional study on behalf of the Korean Society of Pediatric Hematology and Oncology.: Psycho-oncology. 27(9):2257~2264 (3.455)

2017 SCI-E Nationwide Statistical Analysis of Lymphoid Malignancies in Korea: Cancer Research and Treatment. 50(1):222~238 (3.772)

2017 SCI-E Gonadal and Sexual Dysfunction in Childhood Cancer Survivors: Cancer Research and Treatment. Online:Published (3.772)

2017 SCI-E Awareness about past diagnosis and treatment history: nationwide survey of childhood cancer survivors and their parents: Japanese journal of clinical oncology. 47(10):962~968 (1.905)

2017 SCI Outcome of reinduction chemotherapy with a modified dose of idarubicin for children with marrow-relapsed acute lymphoblastic leukemia: Results of the childhood acute lymphoblastic leukemia (CALL)-0633 study: Journal of Korean Medical Science. 32(4):642~649 (1.459)

2017 SCI Regulation of Anoikis Resistance by NADPH Oxidase 4 and Epidermal Growth Factor Receptor: British Journal of Cancer. 116(3):370~381 (6.176)

2016 SCI Higher Gemcitabine dose was associated with better outcome of osteosarcoma patients receving Gemcitabine-Docetaxel chemotherapy: Pediatric Blood and Cancer. 63(9):1552~1556 (2.634)

2016 SCI Characteristics and outcomes of second malignant neoplasms after childhood cancer treatment: Multi-center retrospective survey: Journal of Korean Medical Science. 31(8):1254~1261 (1.256)

2016 SCI-E Incidence and Survival of Childhood Cancer in Korea: Cancer Research and Treatment. 48(3):869~882 (4.245)

2016 기타 A case of Langerhans cell histiocytosis manifested as a suprasellar mass: Brain Tumor Research and Treatment. 4:26~29 ()

2015 기타 Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012: BLOOD RESEARCH. 50(4):204~217 (0)

2015 SCI-E Acute Raoultella planticola cystitis in a child with rhabdomyosarcoma of the bladder neck.: Pediatrics International. 57:985~987 (0.73)

2014 SCI-E Diffuse cerebral vasospasm with infarct after intrathecal cytarabine in childhood leukemia: Pediatrics international. 56(6):921~924 (0.731)

2014 기타 A Case of Childhood Paroxysmal Cold Hemoglobinuria Related with Suspicious Chlamydia Infection: Clinical Pediatric Hematology-Oncology. 21(2):135~139 (0)

2014 SCI Ewing sarcoma/peripheral primitive neuroectodermal tumor in the adrenal gland of an adolescent: A case report and review of the literature: Journal of pediatric hematology/oncology. 36(7):e456~e459 (0.956)

2014 SCI-E A study of docetaxel and irinotecan in children and young adults with recurrent or refractory Ewing sarcoma family of tumors: BMC Cancer. 14:622~622 (3.319)

2014 SCI Exploring the association between DICER1 mutations and differentiated thyroid carcinoma: Journal of the clinical endocrinoplogy and metabolism. 99(6):E1072~E1077 (6.31)

2014 기타 Huge Intrathoracic Malignant Peripheral Nerve Sheath Tumor in an Adolescent with Neurofibromatosis Type 1: Case reports in pediatrics. 2014:951252~951252 (0)

2014 SCI-E Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells: Cell death & disease. 5:e1224~e1224 (5.177)

2014 SCI-E Cancer Incidence and Survival among Adolescents and Young Adults in Korea: PloS One. 9(5):e96088~e96088 (3.534)

2014 SCI Clinical features and treatment outcomes of Langerhans cell histiocytosis: A nationwide survey from Korea Histiocytosis Working Party: Journal of pediatric hematology/oncology. 36(2):125~133 (0.956)

2013 기타 A Comparison of the Correlations between the Disgust Sensitivity and Pain-fear Association in Children and Adolescent Patients with Cancer against Non-patient Children and Adolescents: The Korean Journal of Health Psychology. 18(4):869~879 (0)

2013 SCI Cross-Cultural Adaptation of the Korean Version of the Minneapolis-Manchester Quality of Life Instrument-Adolescent Form: Journal of Korean medical science. 28(12):1788~1795 (1.249)

2013 기타 Early-onset Pericardial Effusion after Autologous Hematopoietic Stem Cell Transplantation in a Child with Neuroblastoma: Clinical Pediatric Hematology-Oncololgy. 20(2):121~125 (0)

2013 SCI An infant with prenatally diagnosed congenital anaplastic astrocytoma who remains disesase-free after proton therapy: Journal of Korean Medical Science. 28:1394~1398 (1.249)

2013 SCI-E Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2: Cell Death and Disease. 4:e693~e693 (6.044)

2013 SCI-E Langerhans cell histiocytosis in non-twin siblings: Pediatrics International. 55(3):e73~e76 (0.875)

2013 SCI-E Safety and effects of prophylactic defibrotide for sinusoidal obstruction syndrome in hematopoietic stem cell transplantation: Ann Transplant. 18:36~42 (0.815)

2012 기타 6-Thioguanine-Induced Hepatic Sinusoidal Obstruction Syndrome in a Leukemic Child with TPMT Heterozygote: Clinical Pediatric Hematology and Oncology. 19(2):109~113 (0)

2012 SCI Follicular thyroid carcinoma arising after stem cell transplantation in a child with pleuropulmonary blastoma: Thyroid. 225(5):547~551 (4.792)

2012 SCI Hemophagocytic lymphohistiocytosis can mimic the superior vena cava syndrome.: Journal of Pediatric Hematology Oncology. 34(4):e152~e154 (1.159)

2012 기타 Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008.: Korean Journal of Hematology. 47:28~38 (0)

2012 SCI Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma: European Journal of Nuclear Medicine and Molecular Imaging. 39(1):39~49 (4.991)

2011 SCI Craniospinal Irradiation Techniques: A Dosimetric Comparison of Proton Beams with Standard and Advanced Photon Radiotherapy.: International journal of radiation oncology, biology, physics. 81(3):637~646 (4.503)

2011 SCI Interferon consensus sequence binding protein-induced cell proliferation is mediated by TGF-β signaling and p38 MAPK activation.: Laboratory Investigation. 91(9):1304~1313 (4.405)

2011 기타 Ewing sarcoma/peripheral primitive neuroectodermal tumor in an adolesence, manifeted as isolated cervical mass: Clinical Pediatric Hematology-Oncology. 18(1):70~74 (0)

2011 기타 The impact of HLA matching on unrelated donor hematopoietic stem cell transplantation in Korean children: Korean J Hematol. 46(1):11~17 (0)

2011 SCI Current status of pediatric umbilical cord blood transplantation in Korea: A multicenter retrospective analysis of 236 cases: American Journal of Hematology. 86(1):12~17 (3.576)

2010 SCI Efficacy of high-dose chemotherapy and autologoys stem cell trasnplantation in patients with relapsed medulloblastoma: A report on the Korean Society for pediatric neuro-oncology(KSPNO)-S-053 study: Journal of Korean Medical Science. 25:1160~1166 (0.838)

2010 SCI Hepatic veno-occulsive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome.: Bone Marrow Transplantation. 45(8):1287~1293 (2.998)

2010 SCI Induction of apoptosis by ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt: British Journal of Pharmacology. 160:1212~1223 (5.204)

2010 SCI Normalization of red cell enolase level following allogeneic bone marrow transplantation in a child with Diamond-Blackfan anemia.: Journal of Korean medical science. 25(4):626~629 (0.838)

2010 SCI-E Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification: Clinical Imaging. 34/(1):47~52 (0.725)

2009 SCI HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress.: carcinogenesis. 30:1997~2004 (4.93)

2009 SCI Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization: Journal of Pathology. 218(3):337~49 (5.121)

2009 기타 Family of Li-Fraumeni syndrome with a germline mutation in the p53 gene: 임상소아혈액종양. 16:38~42 ()

2008 SCI Adenocarcinoma of lung in never smoked children.: Lung Cancer. 61:266~269 (3.455)

2007 기타 A case of ganglioneuroblastoma presenting as weakness of the lower extremities: 대한혈액학회지. 42:414~418 ()

2007 기타 Outcome of multicenter study for Korean children with medulloblastoma: 임상소아혈액종양. 14:167~175 ()

2007 SCI The heat shock protein 90 inhibitor, geldanamycin induces apoptotic cell death in Ebstein-Barr virus-positive NK/T cell lymphoma by Akt downregulation.: Journal of Pathology. 213:170~179 (5.759)

2006 SCI Lingual alveolar soft part sarcoma tretated only by conservative resection: Int J Pediatr Otorhinolaryngol. 1:243~248 (0.846)

2006 기타 Current status of hematopoietic stem cell transplantation in Korean children: 대한혈액학회지. 41:235~242 ()

2005 SCI Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia: Leukemia Research. 29:617~623 (2.244)

2004 기타 Epidemiology and clinical outcomes in children with malignant lymphoma in Korea: retrospective study: 대한소아혈액종양학회지. 11:153~163 ()

2004 기타 Hepatoblastoma: 소아과. 47:456~462 ()

2002 기타 유방암세포주에서 고농도 5-fluorouracil의 세포주기 조절효과: Immune Network. 2:60~64 ()

2001 기타 자가 말초혈 조혈모세포이식으로 장기간 관해를 보인 영아의 가족성 혈구탐식성 림프조직구증: 대한혈액학회지. 36:346~350 ()

2001 기타 Interferon consensus sequence binding protein: Not essential for interferon a-mediated antiviral response to vesicular stomatitis virus infection in HL-60 cells: Immune Network. 1:109~115 ()

2001 SCI Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: Implication for the loss of TGF-b type II receptor expression: Oncogene. 20:1235~1245 (6.87)

2001 기타 경남지역 소아백혈병 환자 발생빈도에 관한 연구: 대한소아혈액종양학회지. 8:27~34 ()

2001 SCI Implication of co-measured platelet factor 4 in the reliability of the results of the plasma transforming growth factor-b1 measurement: Cytokine. 16:102~105 (2.01)

2001 기타 2개월 남아에서 발병한 Malignant Ectomesenchymoma: 소아과. 44:959~964 ()

2000 기타 연소형 과립막 세포종(Juvenile Granulosa Cell Tumor) 2례: 대한소아혈액종양학회지. 7:146~152 ()

2000 기타 백혈병 세포주의 Transforming Growth Factor-b (TGF-b) 수용체 발현 양상과 TGF-b1의 성장 억제 효과에 대한 반응성: 대한혈액학회지. 35:150~161 ()

2000 기타 Ubiquitin-proteasome 경로에 의한 Retinoblastoma Family Protein p107의 단백분해에 관한 연구: 대한암학회지. 32:417~421 ()

2000 기타 Wild-type p53 유전자가 결여된 암세포에서 Cyclic AMP의 세포주기 조절기작에 관한 연구: 대한암학회지. 32:750~756 ()

2000 기타 Retroviral vector에 의해 JC 유방암 세포에 형질도입된 Transforming Growth Factor-b (TGF-b) 2형 수용체가 TGF-b에 대한 반응성에 미치는 효과: 한국 BRM 학회지. 10:37~47 ()

2000 SCI Deletion of one adenine base within the polyadenine tract of transforming growth factor-b receptor type II in human MDA-MB-231 breast cancer cell line: International J Oncology. 17:473~478 (2.68)

2000 SCI Microsatellite instability(MSI) in non-small cell lung cancer(NSCLC) is highly associated with transforming growth factor-b type II receptor(TGF-b RII) frameshift mutation: Anticancer Res. 20:1499~1502 (1.6)

2000 기타 경남지역에서 감염성 설사와 관련된 영아 일과성 메트헤모글로빈혈증의 최근 10년간 변화: 소아과. 43:1569~1575 ()

1999 기타 암 환자의 혈장 Transforming Growth Factor-b1 농도: 대한의생명과학회지. 5:181~190 ()

1998 기타 뇌막염 환아에서 반복적으로 측정한 혈청 Transforming Growth Factor-b1 농도와 말초혈액의 T4/T8 림프구 비의 변동상: 한국 BRM 학회지. 9:79~88 ()

1998 기타 한국인 고셔 환자 등록: 대한소아혈액종양학회지. 5:44~53 ()

1998 기타 자매에서 발견된 Hemophilia C 2예: 소아과. 41:401~404 ()

1997 기타 Transforming Growth Factor-b와 암: 대한소아혈액종양학회지. 4:243~251 ()

1996 SCI Inhibition of ligand induced promoter occupancy in vivo by a dominant negative RXR: Genes to Cells. 1:209~221 (3.44)

1995 SCI Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element: J Virology. 69:4173~4181 (5.17)

1994 기타 선천성 부신 과형성을 초래하는 Steroid 21-hydroxylase 유전자(CYP21A2)의 분자 유전학적 연구(I): 대한내분비학회지. 9:219~227 ()

1993 기타 소아 쭈쭈가무시병 환자 28명의 임상상 및 유병기간에 따른 간접면역형광항체가의 변동: 감염. 25:109~123 ()

1993 기타 톡소플라스마 곤디의 세포내 배양에 있어서 세포 주에 따른 감수성 비교: 기생충학잡지. 31:215~222 ()

1992 기타 급성 피부점막 임파절 증후군 환자에서의 관상동맥류의 발현시기, T림프구 및 그 아형의 변화와 감마글로블린 치료의 효과에 대한 연구: 순환기. 22:269~279 ()

1992 기타 소아에서 미주신경 자극시 나타나는 반응도의 개인적 차이에 대한 연구 (비스펙트럴 분석): 순환기. 22:97~105 ()

1992 기타 특발성 폐섬유화증 2례: 소아과. 35:122~128 ()

1990 기타 성장호르몬 결핍증 환아에서 성장호르몬 분비인자에 대한 성장호르몬 분비 양상: 대한내분비학회지. 5:14~22 ()

1990 기타 소아의 흉막삼출액 (농흉을 중심으로): 경상대학교 의과대학보. 4:49~53 ()

1990 기타 신생아 초기의 폐동맥압의 변화에 대한 연구: 소아과. 33:1081~1086 ()

1990 기타 소아 Mycoplasma pneumoniae 감염의 임상적 고찰: 소아과. 33:315~323 ()

1990 기타 소아의 황색 포도상구균 감염증에 대한 임상적 고찰: 소아과. 33:35~41 ()

1989 기타 성홍열과 동시에 발현한 Henoch-Schonlein 자반증 1례: 소아과. 32:1581~1585 ()

1989 기타 소아 백혈병에서의 감염에 대한 연구: 소아과. 32:659~664 ()

1988 기타 심실 중격결손증에서 Doppler 심에코도를 이용한 좌우 심실 압력차이 측정: 소아과. 31:315~321 ()

1988 기타 소아에서의 encapsulated enteric-coated pellet form of erythromycin(Eryc)의 임상 경험: 대한화학요법학회지. 6:110~115 ()

1987 기타 A Case of Common Variable Immunodeficiency: 서울의대학술지. 28:155~161 ()

1987 기타 Takayasu 동맥염의 경피적 혈관성형술 4례: 소아과. 30:441~449 ()