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Name
Lee, Ho, Ph.D.(full-time professor)
Faculty Appointment
(title, department)

Associate Professor and Department Chair, Department of Cancer Biomedical Science, NCC-GCSP
Senior Scientist, Research Institute, National Cancer Center
Area of Expertise
Mouse Genetics of Cancer Models
Contact no
+82-31-920-2274
E-mail
ho25lee@ncc.re.kr/ho25lee@gmail.com
Previous Appointment(s) Held
Researcher, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Korea
Visiting Scientist, Department of Pediatric and Adolescent Medicine, Mayo Clinic, USA
Educational Background
1994 Seoul National University, Seoul, Korea; Bachelor’s Degree
1996 Seoul National University, Department of Microbiology, Seoul, Korea; Master’s Degree
2001 Seoul National University, School of Biological Sciences, Seoul, Korea; Ph.D.
Research Interests (Please place in paragraph form)
Dr. Lee, Ho, earned his PhD from Seoul National University, Korea, and has performed a three-year postdoctoral research in the field of cell cycle regulation and mouse genetics in the Department of Biological Sciences at Korea Advanced
Institute of Science and Technology, Korea. Following that, Dr Lee joined the Research Institute of National Cancer Center as a junior faculty member staff.
His current research interests include mouse genetics of cancer models and pluripotency and differentiation in embryonic/adult stem cell.
International Collaboration
2017 SCI RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network: nature communications. 8(1):162~162 (12.124)

2017 SCI Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity: Cell Reports. 20:832~845 (8.282)

2017 SCI-E Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction: Oncotarget. 8(19):31842~31855 (5.168)

2017 SCI-E The Hippo signaling pathway provides novel anti-cancer drug targets: Oncotarget. 8(9):16084~16098 (5.008)

2017 SCI Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes.: Journal of Investigative Dermatology. 137(2):414~421 (6.915)

2016 SCI Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis: Life Science. 166:13~19 (2.685)

2016 SCI Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes: Cell Death Differentiation. 23(11):1804~1814 (8.218)

2016 SCI Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.: Biochimica et biophysica acta - Molecular Basis of Disease. 1862(9):1533~1543 (5.158)

2016 SCI Lats-Yap/Taz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development: Nature Communications. 7:11961~11961 (11.329)

2016 SCI CD81/Kai1 maintains the dormancy of long-term hematopoietic stem cells through interaction with DARC-expressing macrophages: Cell Stem Cell. 18(4):508 ~521 (22.387)

2016 SCI Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phhosphatase 2A and G-protein-coupled receptor-12: European journal of pharmacology. 775:86~95 (2.73)

2016 SCI Methylation-dependent Regulation of HIF-1α Stability Restricts Retinal and Tumour Angiogenesis: Nature Communications. 7:10347~10347 (11.329)

2016 SCI Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase.: Hepatology. 63(1):247~259 (11.055)

2015 SCI-E Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB singaling: Oncotarget [electronic resource]. 6(14):12529~12542 (6.359)

2015 SCI Pontin Functions as an Essential Coactivator for Oct4-Dependent LincRNA expression in Mouse Embryonic Stem Cells: Nature communications [electronic resource]. 6:6810~6810 (11.47)

2015 SCI-E Cardamonin Suppresses TGF-β1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression.: Biomolecules & therapeutics. 23(2):141~148 (1.727)

2014 SCI Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination: The Journal of clinical investigation. 124(11):4976~4988 (13.765)

2014 SCI-E Genetically Engineered Mouse Models for Drug Development and Preclinical Trials: Biomolecules & therapeutics. 22(4):267~274 (0.841)

2014 기타 OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice: Oncogenesis. 3:e109~e109 (0)

2014 SCI Pontin is required for pre-TCR signaling at the β-selection checkpoint in T cell development: Biochemical and Biophysical Research Communications. 447(1):44~50 (2.281)

2014 SCI Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting: Molecular Cell. 53(5):791~805 (14.464)

2014 SCI TopBP1 deficiency impairs V(D)J recombination during lymphocyte development: The EMBO journal. 33(3):217~228 (10.748)

2013 SCI Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion: Nature communications. 302(4):2631~2631 (10.015)

2013 SCI cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.: EMBO journal. 32(11):1543~1555 (9.822)

2013 SCI CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner: European Journal of Immunology. 43(3):667~678 (4.97)

2012 SCI Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation.: Biomolecules & Therapeutics. 20:380~385 (0.694)

2012 SCI-E O-GlcNAcase is essential for embryonic development and maintenance of genomic stability: Aging Cell. 11(3):439~448 (6.265)

2012 SCI Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading: Molecular Cell. 46(3):260~273 (14.178)

2012 SCI The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development: The Journal of Immunology. 188(8):3791~3803 (5.788)

2012 SCI Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation: Cell Death and Diffrentiation. 19(2):321~332 (8.849)

2012 SCI TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/sepinB2 and transglutaminase 2: Proc. Natl. Acad. Sci. USA. 109(4):e177~e186 (9.681)

2011 SCI Cancer cells promote survival through depletion of the von Hippel Lindau tumor suppressor by protein crosslinking: Oncogene. 30(48):4780~4790 (7.414)

2011 SCI Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813(10):1777~1783 (4.733)

2011 SCI TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells: The Journal of biological chemistry. 286(7):5414~5422 (5.328)

2010 SCI Transglutaminase 2 gene ablation protects against renal ischemic injury by blocking constant NF-κB activation.: Biochemical and biophysical research coommunications. 403:479~484 (2.548)

2010 SCI The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion: EMBO Journal. 29:3544~3557 (8.993)

2010 SCI Negative Regulation of Hypoxic Responses via Induced Reptin Methylation: Molecular Cell. 39:71~85 (14.608)

2008 SCI Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation: FEBS Letters. 582:2319~2324 (3.263)

2008 SCI ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification: Cell Stem Cell. 2:497~507 (16.826)

2007 SCI The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels: Biochemical and Biophysical Research Communications. 360:333~338 (2.855)

2007 SCI Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkc activation: Biochemical and Biophysical Research Communications. 354:184~189 (2.855)

2006 SCI Mouse emi1 has an essential function in mitotic progression during early embryogenesis: Molecular and Cellular Biology. 26:5373~5381 (7.093)

2005 SCI The Centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles: Journal of biological chemistry. 280:3920~3927 (5.854)

2004 SCI The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex: Nature Cell Biology. 6:129~137 (19.717)

2003 SCI Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage: Molecular Cancer Research. 1:674~681 (4.317)

2003 SCI Sequential binding of SeqA to paired hemi-methylated GATC sequences mediates formation of higher order complexes.: Journal of Biological Chemistry. 278:34983~34989 (5.854)

2001 SCI SeqA protein aggregation is necessary for SeqA function.: Journal of Biological Chemistry. 276:34600~34606 (5.854)

2001 SCI Expression of the seqA gene is negatively modulated by the HU protein in Escherichia coli: Mol Gen Genet. 264:931~935 ()

1999 SCI Interaction of SeqA and Dam methylase on the hemimethylated origin of Escherichia coli chromosomal DNA replication.: Journal of Biological Chemistry. 274:11463~11468 ()

1997 SCI The binding of two dimers of IciA protein to the dnaA promoter 1P element enhances the binding of RNA polymerase to the dnaA promoter 1P.: Nucleic Acid Research. 25:3486~3489 ()

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