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Name
Yoo, Heon, M.D., Ph.D.(adjunct professor)
Faculty Appointment



Professor, Department of Cancer Biomedical Science, NCC-GCSP/Head of Center for Specific Organs Cancer, National Cancer Center Hospital/ Chief of Specific Organs Cancer Branch, National Cancer Center Research Institute
Area of Expertise
Neurosurgery
Contact no
+82-31-920-2435
E-mail
heonyoo@ncc.re.kr
Previous Appointment(s) Held
Assistant professor, Department of Neurosurgery, Inje University Seoul Paik Hospital
Research fellow, UCSF Department of Neurosurgery, Brain Tumor Research Center
Visiting professor, College of Medicine, Seoul National University
Educational Background
1989 Seoul National University College of Medicine (M.D.)
1993 Seoul National University Graduate School of Medicine (M.S.)
2001 Seoul National University Graduate School of Medicine (Ph.D.)
Research Interests (Please place in paragraph form)
Malignant brain tumors (glioma, metastatic brain tumors)
Benign brain tumors (meningioma, schwannoma)
Skull base tumor
Hyperthermia for malignant brain tumors
Immunotherapy for malignantgliomas
Leptomeningealcarcinomatosis
International Collaboration
Member, World Federation of Neuro-Oncology Member, Asian Society for Neuro-Oncology
2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. Online:Published (5.168)

2017 SCI Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBPβ signaling: Cancer Research. Online:Published (9.122)

2017 SCI-E Monitoring rate and predictability of intraoperative monitoring in patients with intradural extramedullary and epidural metastatic spinal tumors: Spinal cord. Online:Published (1.87)

2017 기타 An Updated Nationwide Epidemiology of Primary Brain Tumors in Republic of Korea, 2013: Brain Tumor Research Treatment. 5(1):16~23 ()

2016 SCI-E Nationwide Population-based Incidence and Survival rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012: Cancer Research and Treatment. 49(2):494~501 (4.245)

2016 SCI-E Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea.: Cancer Research and Treatment. 49(1):193~203 (4.245)

2016 SCI-E Retrospective Analysis of Cerebrospinal Fluid Profiles in 228 Patients with Leptomeningeal Carcinomatosis : Differences According to the Sampling Site, Symptoms, and Systemic Factors.: Journal of Korean Neurosurgical Society. 59(6):570~576 (0.599)

2016 SCI Histone variant H3F3A promotes lung cancer cell migration through intronic regulation: Nature Communications. 7:12914~12914 (11.329)

2016 SCI Review of Neurosurgical Fluorescence Imaging Systems for Clinical Application: Journal of the Optical Society of Korea(OSA). 20(2):305~313 (0.827)

2016 기타 A Case of Langerhans Cell Histiocytosis Manifested as a Suprasellar Mass: Brain Tumor Research and Treatment. 4:26~29 ()

2015 SCI-E Percutaneous vertebroplasty for patients with metastatic compression fractures of the thoracolumbar spine: clinical and radiological factors affecting functional outcomes: The spine journal : official journal of the North American Spine Society. 16(3):355~364 (2.426)

2015 SCI Clinical characteristics and follow-up of intracranial metastases from thyroid cancer: Acta neurochirurgica. 157(12):2185~2194 (1.766)

2015 기타 The Efficacy of Postoperative Chemotherapy for Patients with Metastatic Brain Tumors from Non-Small Cell Lung Cancer.: Brain Tumor Research and Treatment. 3(2):108~114 (0)

2015 기타 A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma.: Brain Tumor Research and Treatment. 3(2):156~159 (0)

2015 SCI-E Population-Based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009: Cancer Research and Treatment. 47(4):569~574 (3.318)

2015 SCI-E Clinical Factors and Perioperative Strategies Associated with Outcome in Preinjury Antiplatelet and Anticoagulation Therapy for patients with Traumatic Brain Injuries: Journal of Korean Neurosurgical Society. 58:262~270 (0.636)

2015 SCI DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis: Brain. 138(Pt9):2553~2570 (9.196)

2015 SCI-E Recent Advancements of Treatment for Leptomeningeal Carcinomatosis: Journal of Korean Neurosurgical Society. 58(1):1~8 (0.636)

2015 SCI Acute intracranial bleeding and recurrence after bur hole craniostomy for chronic subdural hematoma: Journal of neurosurgery. 123(1):65~74 (3.737)

2015 SCI Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells: PLoS biology. 13(5):1002152~1002152 (9.343)

2015 기타 A case of benign meningioma presented with subdural hemorrhage: Brain Tumor Research and Treatment. 3(1):30~33 (0)

2015 SCI-E Incidence of Primary Spinal Cord, Spinal Meninges, and Cauda Equina Tumors in Korea, 2006-2010: Cancer research and treatment. 47(2):166~172 (3.318)

2015 SCI-E Radiation-induced autophagy contributes to cell death and induces apoptosis partly in malignant glioma cells.: Cancer research and treatment. 47(2):221~241 (3.318)

2015 기타 Study of a Brain tumore and blood vessel detection system usgin multiple fluorescence imaging by surgical microscope: 한국광학회지. 26:23~29 (0)

2015 기타 Development of Indocyanine Green and 5-Aminolevulinic Acid Detection System for Surgical Microscope: 대한의용생체공학회. 36:16~21 (0)

2014 기타 Extraneural Metastases of Glioblastoma without Simultaneous Central Nervous System Recurrence: Brain tumor research and treatment. 2(2):124~127 (0)

2014 SCI-E Ventriculolumbar Perfusion Chemotherapy With Methotrexate for Treating Leptomeningeal Carcinomatosis: A Phase II Study.: The oncologist. 19(10):1044~1045 (4.54)

2014 SCI-E CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression: Oncotarget. 5(16):6756~6769 (6.627)

2014 SCI The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein: Biochimica et biophysica acta-Gene Regulatory Mechanisms. 1839(5):374~386 (5.44)

2014 기타 Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development: Brain tumor research and treatment. 2(1):1~6 (0)

2014 SCI Steroid-resistant relapsing IgG4-related pachymeningitis treated with methotrexate: JAMA Neurol. 71(2):222~225 (7.008)

2014 기타 Outcome of Surgical Resection of Symptomatic Cerebral Lesions in Non-Small Cell Lung Cancer Patients with Multiple Brain Metastases: Brain tumor research and treatment. 1(2):64~70 (0)

2013 SCI The volumetric change and dose-response relationship following hypofractionated proton therapy for chordomas: Acta Oncologica. 53(4):563~568 (3.71)

2013 SCI-E Temozolomide salvage chemotherapy for recurrent anaplastic oligodendroglioma and oligo-astrocytoma.: Journal of Korean Neurosurgical Society. 54(6):489~495 (0.556)

2013 기타 Assessment of effects of phlebotomy in patients with polycythemia vera and secondary polycythemia: 대한수혈학회지. 24(3):265~274 (0)

2013 SCI Analysis of treatment outcomes of intraventricular chemotherapy in 105 patients for leptomeningeal carcinomatosis from non-small-cell lung cancer.: Journal of thoracic oncology. 8(5):599~605 (4.473)

2013 기타 An updated nationwide epidemiology of primary brain tumors in Republic of Korea: Brain Tumor Research and Treatment. 1:16~23 (0)

2013 SCI-E Non small cell carcinoma metastasis to meningioma: Journal of Korean Neurosurgical Society. 53(1):43~45 (0.556)

2012 SCI-E Single-stage posterior decompression and stabilization for metastasis of the thoracic spine: prognostic factors for functional outcome and patients' survival.: The spine journal. 12)12_:1083~1092 (3.29)

2012 SCI-E Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines.: PLOS ONE. 7(10):e47449~e47449 (4.092)

2012 SCI Population-based survival data for brain tumors in Korea: Journal of Neuro-Oncology. 109(2):301~307 (3.214)

2012 SCI Ventriculolumbar Perfusion Chemotherapy for the Treatment of Leptomeningeal Carcinomatosis: A Phase I Study With Pharmacokinetic Data.: American journal of clinical oncology. Online:Published (2.005)

2012 SCI Risk for leptomeningeal seeding after resection for brain metastases: implication of tumor location with mode of resection.: Journal of Neurosurgery. 116(5):984~993 (2.965)

2012 SCI-E Volumetric response evaluation after intensity modulated radiotherapy in patients with supratentorial gliomas: Technology in Cancer Research & Treatment. 11(1):41~48 (1.692)

2011 SCI-E PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1: PLoS ONE. 6(12):e28308~e28308 (4.411)

2011 SCI Human Brain Endothelial Cell-derived COX-2 Facilitates Extravasation of Breast Cancer Cells across the Blood-brain Barrier: Anticancer Research. 31(12):4307~4313 (1.656)

2011 SCI-E Chemotherapy for malignant gliomas based on histoculture drug response assay: a pilot study: Journal of Korean Neurosurgical Society. 50:426~433 (0.607)

2011 SCI Single-Dose Versus Fractionated Stereotactic Radiotherapy for Brain Metastases: International Journal of Radiation Oncology, Biology and Physics. 81(2):483~489 (4.503)

2011 SCI Chemoport with a non-collapsible chamber as a replacement for an Ommaya reservoir in the treatment of leptomeningeal carcinomatosis: Acta Neurochirugica. 153:1971~1978 (1.329)

2011 기타 Postoperative recurrence and growth rate of cystic brain metastases: Journal of Korean Brain Tumor Society. 10:91~96 ()

2011 SCI Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models: Biomaterials. 32:5252~5261 (7.883)

2011 SCI-E Surgical outcomes of hemorrhagic metastatic brain tumors: Cancer Research and Treatment. 43(2):102~107 ()

2011 SCI Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas: Oncogene. 30(21):2433~2442 (7.414)

2011 SCI Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer: Lung Cancer. 71(2):205~208 (3.356)

2010 SCI Simultaneous Integrated Boost Intensity-Modulated Radiotherapy in Patients with High-Grade Gliomas: International journal of radiation oncology, biology, physics. 78(2):390~397 (4.592)

2010 기타 Histoculture drug response assay for brain tumors: a preliminary study for evaluability and compatibility: Journal of Korean Brain Tumor Society. 9:67~73 ()

2010 SCI-E Epidemiology of Primary Brain and Central Nervous System Tumors in Korea: Journal of Korean Neurosurgical Society. 48(2):145~152 (0.155)

2010 SCI-E Cytogenetic study of glioneuronal tumor with neuropil-like islands: Neuropathology. 30(4):420~426 (1.861)

2010 SCI The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis: International Journal of Molecular Medicine. 26:3~9 (1.98)

2009 기타 Giant Invasive Intraosseous Schwannoma in Lumbar Spine: Korean Journal of Spine. 6:214~217 (0)

2009 기타 Clinical application of anti-epileptic drugs in the field of neuro-oncology: Jounal of Korean Brain Tumor Society. 8:3~15 (0)

2009 기타 Primary T-cell central nervous system lymphoma: Journal of Korean Brain Tumor Society. 8:72~75 ()

2008 SCI Reduced local recurrence of a single brain metastasis through microscopic total resection: Journal of Neurosurgery. 110(4):730~736 (2.124)

2008 SCI 17-Allylamino-17-Demethoxygeldanamycin Down-Regulates Hyaluronic Acid-Induced Glioma Invasion by Blocking Matrix Metalloproteinase-9 Secretion: Molecular Cancer Research. 6:1657~1665 (4.317)

2008 SCI Growth rates of metastatic brain tumors in nonsmall cell lung cancer: Cancer. 113:1043~1047 (4.632)

2008 SCI Primary chemotherapy for newly diagnosed nonsmall cell lung cancer patients with synchronous brain metastases compared with whole-brain radiotherapy administered first : result of a randomized pilot study: Cancer. 113:143~149 (4.632)

2008 기타 The Efficacy of Wide Surgical Resection of Brain Metastasis with Confirming Clean Surgical Margin by Intraoperative Margin Biopsy: Journal of Korean Brain Tumor Society. 7:16~25 ()

2008 기타 Remote Cerebellar Hemorrhaeg after Supratentorial meningioma Surgery: Journal of korean Brain Tumor Society. 7:50~54 (0)

2007 기타 Radiation-induced necrosis deteriorating neurological symptoms and mimicking progression of brain metastasis after stereotactic guideded radiotherapy: Cancer Research and Treatment. 39:16~21 ()

2007 SCI Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas: Clinical Cancer Research. 13:68~75 (6.25)

2006 기타 Result of adjuvant therapy after metastatectomy for brain metastasis from non-small cell lung cancer: Journal of Korean Brain Tumor Society. 5:77~84 ()

2005 SCI Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of gliom cells: International Journal of Oncology. 27:839~846 (3.056)

2005 SCI Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma: Journal of Neuro-Oncology. 74:1~8 (0.325)

2005 SCI Hyaluronic acid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells: Cancer Research. 65:686~691 (8.649)

2004 SCI Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line: International Journal of Molecular Medicine. 13:883~887 (3.19)

2004 기타 Anterior spinal augmentation using vertebroplasty after partial corpectomy in metastatic spinal tumors: Korean Journal of Spine. 1:218~223 ()

2003 기타 Metastatectomy a feasible treatment in selected patients with gynecologic malignancy: Korean Journal of Obstetrics and Gynecology. 46:1019~1026 ()

2002 SCI-E Surgical management of dural arteriovenous fistula of the anterior cranial fossa after failure of embolization therapy: Journal of Korean Neurosurgical Society. 31:271~273 ()

2002 SCI-E Atretic cephalocele: Journal of Korean Neurosurgical Society. 31:380~383 ()

2002 기타 Hemorrhagic presentation of a vestibular schwannoma: Journal of Korean Brain Tumor Society. 1:78~80 ()

2002 SCI PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation: CANCER RES. 62:6318~6322 (8.318)

2001 SCI-E A fatal complication associated with combined posterior petrous and suboccipital approach to a giant jugular foramen schwannoma: Journal of Korean Neurosurgical Society. 30:1144~1149 ()

2001 SCI Multiple meningiomas of different pathological features: case report.: Journal of Clinical Neuroscience. 8:40~43 (0.543)

2001 SCI An angiographic lesion mimicking pseudo-aneurysm in cerebral arteriovenous malformation: Acta Neurochirurgica. 143:1177~1181 (0.779)

2001 SCI Epithelioid hemangioendothelioma of the sphenoid bone: Journal of Clinical Neuroscience. 8:1~4 (0.543)

2000 SCI-E Repeated transsphenoidal surgery for pituitary tumors: Jornal of Korean Neurosurgical Society. 29:929~934 ()

2000 SCI-E Treatment outcome and prognostic factors of Cushing's disease in adults: Journal of Korean Neurosurgical Society. 29:1316~1321 ()

2000 SCI-E Infantile myofibromatosis of the skull: Journal of Korean Neurosurgical Society. 29:430~433 ()

2000 SCI Meningioma manifestating intracerebral hemorrhage: a possible mechanism of hemorrhage: Acta Neurochirurgica. 142:165~168 (0.779)

2000 SCI Longterm outcome and growth rate of subtotally resected petroclival meningioma: experience of 38 cases: Neurosurgery. 46:567~575 (2.896)

1999 SCI-E Sparganosis of brain and lumbar spinal canal: Journal of Korean Neurosurgical Society. 28:1028~1031 ()

1999 SCI-E Clinical analysis of 178 metastatic brain tumors: Journal of Korean Neurosurgical Society. 28:1185~1193 ()

1999 SCI-E Surgical treatment of metastatic spinal tumor: Journal of Korean Neurosurgical Society. 28:1491~1497 ()

1999 SCI-E Hypoglossal neurinoma without preoperative hypoglossal nerve palsy: Journal of Korean Neurosurgical Society. 28:1800~1804 ()

1999 SCI-E Neurenteric cyst of the posterior cranial fossa: Journal of Korean Neurosurgical Society. 28:843~848 ()

1999 SCI-E Brainstem glioma -survival and prognostic factors-: Journal of Korean Neurosurgiccal Society. 28:1556~1568 ()

1999 SCI-E Modified transpetrosal (mini-petrosal) approach to petroclival tumors: technical note: Journal of Korean Neurosurgical Society. 28:406~413 ()

1999 SCI-E One-stage vertebral reconstruction combined with posterior instrumentation by posterolateral approach for spinal metastasis: Journal of Korean Neurosurgical Society. 28:1485~1490 ()

1999 SCI Jugular foramen schwannomas: surgical approaches and outcome of treatment: Skull Base Surgery. 9:243~252 (0.121)

1999 SCI Multiple intraparenchyma schwannomas in the cerebellum, brainstem, and cervical spinal cord: Acta Neurochirurgica. 141:779~780 (0.779)

1998 SCI-E Experience with an image-guided surgery device -CANS navigator-: Journal of Korean Neurosurgical Society. 27:71~79 ()

1997 SCI-E Jugular foramen schwannomas: Journal of Korean Neurosurgical Society. 26:1705~1713 ()

1994 SCI Morphological study of surgically induced open neural tube defects in chick embryos -postoperative 24 hours-: Journal of Korean Medical Science. 9:116~122 ()

1993 SCI Preenhanced computed tomographic findings in brain death: Journal of Korean Medical Science. 8:305~307 (0.372)

1992 SCI-E A case of malignant meningioma presented with intracerebral hemorrhage: Journal of Korean Neurosurgical Society. 21:706~710 ()

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