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Name
Kim, Jong Heon, Ph.D.(adjunct professor)
Faculty Appointment
(title, department)


Associate Professor, Department of Cancer Biomedical Science, NCC-GCSP/National Cancer Center Senior Investigator, Cancer Cell & Molecular Biology Branch, Research Institute, National Cancer Center
Area of Expertise

RNA Molecular Biology/Post-transcriptional Regulation of Gene Expression
Contact no
+82-31-920-2204
E-mail
jhkim@ncc.re.kr
Previous Appointment(s) Held
Senior Investigator, Cancer Cell & Molecular Biology Branch, Research Institute, National Cancer Center (2012~present)
Senior Investigator, Carcinogenesis Branch, Research Institute, National Cancer Center (2007~2012)
Post-doctoral Fellow, Program in Molecular Medicine, University of Massachusetts Medical School, USA (2004~2007)
Post-doctoral Fellow, Pohang University of Science and Technology, Korea (2003~2004)
Educational Background
Ph.D. (2003) Pohang University of Science and Technology, Korea
M.S. (1999) Pohang University of Science and Technology, Korea
B.S. (1997) Sung Kyun Kwan University, Korea
Research Interests (Please place in paragraph form)
Dr. Kim, Jong Heon is senior investigator in Cancer Cell & Molecular Biology Branch, Research Institute and he is also associate professor of System Cancer Science department at NCC-GCSP. His current researches are focused on molecular turnover mechanism of oncogenic non-coding RNAs (e.g. microRNAs and IncRNAs) and interplay between non-coding RNAs and RNA-binding proteins/RNA modifiers during tumor genesis.
International Collaboration
Joel D. Richter, University of Massachusetts Medical School, USA
2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. Online:Published (5.168)

2017 SCI CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis: Scientific Reports. 7(1):10666~10666 (4.259)

2017 SCI Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBPβ signaling: Cancer Research. Online:Published (9.122)

2017 SCI-E Inactivation of human DGAT2 by oxidative stress on cysteine residues: PLoS ONE. 12(7):e0181076~e0181076 (2.806)

2017 SCI-E C1QBP is upregulated in colon cancer and binds to apolipoprotein A-I: Experimental and Therapeutic Medicine. 13(5):2493~2500 (1.261)

2016 SCI-E Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116: Oncotarget. 8(4):6819~6823 (5.008)

2016 SCI-E TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling: Oncotarget. 7(48):79854~79868 (5.008)

2016 SCI-E AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks: Oncotarget. 7(33):53642~53653 (5.008)

2016 SCI-E Antiviral activity of micafungin against enterovirus 71: Virology Journal. 13:99~99 (2.362)

2015 SCI DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis: Brain. 138(Pt9):2553~2570 (9.196)

2015 SCI Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells: PLoS biology. 13(5):1002152~1002152 (9.343)

2015 SCI-E Radiation-induced autophagy contributes to cell death and induces apoptosis partly in malignant glioma cells.: Cancer research and treatment. 47(2):221~241 (3.318)

2014 SCI C1QBP and C1QBP-Interacting Proteins in Colon Cancer Cells: Hepato-gastroenterology. IN:PRINT (0.907)

2014 SCI-E CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression: Oncotarget. 5(16):6756~6769 (6.627)

2014 SCI Regulation of Diacylglycerol Acyltransferase 2 (DGAT2) Protein Stability by gp78-Associated ER-associated degradation (ERAD): The FEBS journal. 281(13):3048~3060 (3.986)

2014 SCI The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein: Biochimica et biophysica acta-Gene Regulatory Mechanisms. 1839(5):374~386 (5.44)

2014 기타 Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development: Brain tumor research and treatment. 2(1):1~6 (0)

2014 SCI-E Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells: BMC Cancer. 14:160~160 (3.319)

2013 SCI Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras/Raf-1/ERK/AP-1 signaling pathway: Biochemical Pharmacology. 86(9):1285~1300 (4.576)

2013 SCI-E AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata: Evid Based Complement Alternat Med.. 2013:210736~210736 (1.722)

2012 SCI-E Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines.: PLOS ONE. 7(10):e47449~e47449 (4.092)

2012 SCI Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex: Molecular Cell. 47(2):253~266 (14.178)

2011 SCI-E PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1: PLoS ONE. 6(12):e28308~e28308 (4.411)

2011 SCI Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1: Nucleic Acids Research. 39(17):7791~7802 (7.836)

2011 SCI Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas: Oncogene. 30(21):2433~2442 (7.414)

2008 SCI Measuring CPEB-Mediated Cytoplasmic Polyadenylation-Deadenylation in Xenopus laevis Oocytes and Egg Extracts: Methods in Enzymology. 448:119~138 (2.122)

2008 SCI An RNA-binding protein hnRNP D modulates IRES-dependent translation of HCV RNA: Journal of Virology. 82:12082~12093 (5.332)

2007 SCI BiP IRES activity is controlled by heat-induced interaction of NSAP1: Molecular and Cellular Biology. 27:368~383 (7.822)

2007 SCI RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB: Genes & Development. 21:2571~2579 (17.01)

2006 SCI Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation: Molecular Cell. 24:173~183 (16.811)

2006 SCI PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals: Celluar Signalling. 18:2283~2291 (4.741)

2006 SCI Oscillating Cdk1 and Calcineurin Activities Regulate Maskin Association with eIF4E, Cyclin B1 mRNA Translation, and Cell Cycle Progression: Nature Structural & Molecular Biology. 13:1128~1134 (12)

2005 SCI Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase: Molecular and Cellular Biology. 25:1283~1297 (7.822)

2005 SCI Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation: Molecular and Cellular Biology. 25:3232~3246 (7.822)

2004 SCI Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides: Nucleic Acids Research. 32:1308~1317 (7.26)

2004 SCI A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon: Molecular and Cellular Biology. 24:7878~7890 (7.822)

2003 SCI Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner: Molecular and Cellular Biology. 23:708~720 (7.822)

2000 SCI Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm: Journal of Molecular Biology. 298:395~405 (5.826)

1998 SCI Polypyrimidine tract-binding protein interacts with hnRNP L: FEBS Letters. 425:401~406 (3.843)

1998 SCI Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus: Journal of Virology. 72:8782~8788 (5.398)

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