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Name
Kim, Yun Hee, Ph.D.(adjunct professor)
Faculty Appointment
(title, department)


Associate Professor, Department of Cancer Biomedical Science, NCC-GCSP Senior Scientist, Molecular Imaging & Therapy Branch, Division of Convergence Technology, Research Institute of National Cancer Center
Area of Expertise
Oncology & Cancer Gene Therapy
Contact no
+82-31-920-2514/2526
E-mail
sensia37@ncc.re.kr/sensia37@gmail.com
Previous Appointment(s) Held
2006.03-2007.03 Postdoctoral Fellow, POSTECH
2007.04- present National Cancer Center
Educational Background
1994 Kyunghee University; Biology; B.S.
1996 Yonsei University; Biochemistry; M.S.
2006 Pohang University of Science and Technology (POSTECH) ; Biotechnology; Ph.D.
Research Interests (Please place in paragraph form)
Her current research interests include development of multifunctional cancer theranostics using Aptamer, application of molecular imaging in cancer gene therapy, and investigation of molecular mechanism of pancreatic cancer metastasis.
International Collaboration
2017 SCI Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas: Cancer Letters. 414:181~189 (6.375)

2017 SCI Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.: Experimental & Molecular Medicine. 49(7):e351~e351 (5.063)

2017 SCI-E DCK expression, a potential predictive biomarker in the adjuvant gemcitabine chemotherapy for biliary tract cancer after surgical resection: results from a phase II study: oncotarget. Online:Published (5.168)

2017 SCI Preclinical development of a humanized neutralizing antibody targeting HGF: Experimental & Molecular Medicine. 49(3):e309~e309 (5.063)

2017 SCI-E Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost-Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study: Cancer Research and Treatment. Online:Published (3.772)

2017 SCI-E Tracking Perfluorocarbon Nanoemulsion Delivery by 19F MRI for Precise High Intensity Focused Ultrasound Tumor Ablation: Theranostics. 7(3):562~572 (8.712)

2017 SCI The Effectiveness of Ferritin as a Contrast Agent for Cell Tracking MRI in Mouse Cancer Models: Yonsei Medical Journal. 58(1):51~58 (1.537)

2016 SCI-E C-terminally mutated tubby protein accumulates in aggresomes.: BMB reports. 50(1):37~42 (2.782)

2016 SCI-E Efficacy of pancreatic exocrine replacement therapy for patients with unresectable pancreatic cancer in a randomized trial: Pancreatology. 16(6):1099~1105 (2.406)

2016 SCI An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies: Journal of Controlled Release. 229:1~9 (7.441)

2016 SCI-E DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression: Oncotarget. 7(14):17699~17710 (5.008)

2016 SCI-E Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma: Theranostics. 6:357~368 (8.854)

2014 SCI Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model: Cancer Letters. 344(2):223~231 (5.016)

2014 SCI Bispecific Her2Χ cotinine antibody in combination with cotinine-(histidine) 2-iodine for the pre-targeting of Her2-positive breast cancer xenografts.: Journal of cancer research and clinical oncology. 140(2):227~233 (3.009)

2014 SCI Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8: Biomaterials. 35(1):578~589 (8.312)

2013 SCI Comparative Secretome Analysis of Human Bone Marrow-Derived Mesenchymal Stem Cells During Osteogenesis: journal of cellular physiology. 228(1):216~224 (4.218)

2012 SCI An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human bone marrow-derived mesenchymal stem cells: journal of cellular physiology. 228(3):617~626 (4.218)

2012 SCI DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling: Nature Communications. 3:1296~1296 (7.396)

2012 SCI Wedelolactone Inhibits Adipogenesis Through the ERK Pathway in Human Adipose Tissue-Derived Mesenchymal Stem Cells: journal of cellular biochemistry. 113(11):3436~3445 (2.868)

2012 SCI Over-expression of miR-145 Enhances the Effectiveness of HSVtk gene Therapy for Malignant Glioma: Cancer Letters. 320(1):72~80 (4.238)

2012 SCI Hypoxia-induced up-regulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients: Oral Oncology. 48(6):500~506 (2.857)

2012 기타 Apoptosis of human islet cells by cytokines.: Immune network.. 12(3):113~117 (0)

2011 SCI An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells.: Cancer letters.. 313(1):76~83 (4.864)

2011 SCI A highly sensitive magnetite nanoparticle as a simple and rapid stem cell labelling agent for MRI tracking: Journal of Materials Chemistry. 21:7742~7747 (5.101)

2011 SCI Ochratoxin A inhibits adipogenesis through the ERK-1 PPAR-γ pathway in human adipose tissue-derived mesenchymal stem cells: Stem cells and Development. 20(3):415~426 (4.791)

2010 SCI Subtype-specific role of phospholipase C-β in bradykinin and LPA signaling through differential binding of different PDZ scaffold proteins: Cellular Signalling. 22:1153~1161 (4.094)

2009 SCI-E Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells: BMB reports. 42:685~690 ()

2009 SCI Galectin-3 stabilizes heterogeneous nuclear ribonucleoprotein Q to maintain proliferation of human colon cancer cells: Cellular and Molecular Life Sciences. 66:350~364 (5.511)

2008 SCI Hydrogen Peroxide-Induced VCAM-1 Expression in Pancreatic Islets and beta-Cells Through Extracellular Ca2+ Influx.: Transplantation. 86:1257~1266 (3.641)

2008 SCI Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis: blood. Online:Published (10.896)

2008 SCI Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival: Ann N Y Acad Sci. 1138:393~403 (1.731)

2008 SCI A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity.: Life Sciences. 82:733~740 (2.257)

2008 SCI Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis.: Chemico-Biological Interaction. 171:57~66 (3.09)

2007 SCI Molecular imaging of endogenous mRNA expression in a mouse tumor model by adenovirus harboring trans-splicing ribozyme: FEBS Letters. 28:5396~5400 (3.263)

2007 SCI O-GlcNAc modification modulates the expression of osteocalcin via OSE2 and Runx2: Biochemical and biophysical research communications. 362:325~329 (2.855)

2007 SCI Inhibition of phospholipase C-beta1-mediated signaling by O-GlcNAc modification: J. Cell. Physiol.. 207:689~696 (4.362)

2006 SCI RGS2 promotes formation of neurites by stimulating microtubule polymerization: Cell signal.. 18:2182~2192 (4.4)

2006 SCI Novel compound, CH-223191, prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.: Mol Pharmacol.. 69:1871~1878 (4.612)

2005 SCI 2,2',4,6,6'-Pentachlorobiphenyl-induced apoptosis is limited by cyclooxygenase-2 induction.: Toxicol Sci.. 83:397~404 (3.06)

2005 SCI G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound.: Biochem Pharmacol.. 69:1333~1341 (3.6)

2004 SCI NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.: Mol Cell Biol.. 24:5069~5079 (6.09)

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