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Kim, Hark Kyun

Name
Kim, Hark Kyun, M.D., Ph.D.(adjunct professor)
Faculty Appointment
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise
Medical Oncology, Proteogenomics
Contact no

+82-31-920-2238(Office)/+82-31-920–2255(Lab)
FAX : +82-31-920-2006
E-mail
hkim@ncc.re.kr
Previous Appointment(s) Held
Chief, Biomolecular Function Research Branch (Present)
Medical Oncologist, Center for Gastric Cancer (Present)
Vice President, National Oncoventure (2011-2012)
Educational Background
Ph.D., Seoul National University College of Medicine, Korea, 1996-2000
M.D., Seoul National University College of Medicine, Korea,1985-1991
Clinical Fellow, Seoul National University Hospital, 1999-2000
Research Fellow, Genetics Division, Research Institute of National Cancer Center, Japan, 2000-2001
Research Fellow, Laboratory of Cancer Biology and Genetics, NCI, Bethesda, MD, 2005-2008
Research Interests
Dr. Hark K. Kim’s lab focuses on discovery of cancer genes, diagnostic/predictive biomarkers and therapeutic targets. For these purposes, he is leading comprehensive genomic and proteomic analyses on tumor tissue samples with clinical annotation. Recently, Dr. Kim’s lab has developed the first genetically-engineered mouse models and cell line models for metastatic gastric cancer. Using these preclinical models, he strives to identify novel biomarkers, and molecular mechanisms of putative cancer genes and chemotherapy resistance. Ongoing efforts are being made to develop various genetically-engineered mouse models for gastric cancer that recapitulate human diffuse type gastric cancers. His team also runs a pharmacokinetics/pharmacodynamics and bioanalysis lab to support early phase clinical trials and proteogenomics-guided targeted therapy trials.
International Collaboration
American Association of Cancer Research
American Society of Clinical Oncology
2017 SCI Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma: Cancer Cell. 32(2):185~203 (27.407)

2017 기타 Effect of a Proton Pump Inhibitor on Tumor Bleeding Prevention in Unresectable Gastric Cancer Patients: a Double-Blind, Randomized, Placebo-Controlled Trial: Journal of Gastric Cancer. 17(2):120~131 (0.21)

2017 SCI Sporadic Early-onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations but Low Frequency of Somatic RHOA Mutations Compared with Late-onset Cancers: Gastroenterology. Online:Published (18.392)

2017 SCI Proteogenomic analysis of NCC-S1M, a gastric cancer stem cell-like cell line that responds to anti-PD-1: Biochemical and biophysical research communications (BBRC). 484(3):631~635 (2.466)

2017 SCI Integrated genomic characterization of oesophageal carcinoma.: Nature. 541(7636):169~175 (40.137)

2016 SCI Sca-1 enriches for a cancer stem cell-like subpopulation in mouse gastric cancer: Stem Cells. 34(5):1177~1187 (5.902)

2015 SCI Ablation of osteopontin suppresses N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric cancer development in mice: Carcinogenesis. 36(12):1550~1560 (5.334)

2015 SCI Identification of Protein Markers Specific for Papillary Renal Cell Carcinoma Using Imaging Mass Spectrometry.: Molecules and Cells. 38(7):624~629 (2.09)

2015 SCI-E Multi-dimensional TOF-SIMS analysis for effective profiling of disease-related ions from the tissue surface.: Scientific reports.. 5:11077~11085 (5.578)

2015 SCI Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice: laboratory investigation. 95:660~671 (3.676)

2015 SCI-E Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells.: Oncotarget. 6(10):8132~8143 (6.359)

2014 SCI Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin: Molecular carcinogenesis. Online:Published (4.77)

2014 SCI compact variant-rich customized sequence database and a fast and sensitive database search for efficient proteogenomic analyses.: Proteomics. 14(23-24):2742~2749 (3.973)

2014 SCI Low Expression of miR-449 in Gynecologic Clear Cell Carcinoma: International journal of gynecological cancer. 24(9):1558~1563 (1.949)

2014 SCI Comprehensive molecular characterization of gastric adenocarcinoma.: Nature. 513:202~209 (42.351)

2014 SCI Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis.: Molecular cancer research. 12(8):1088~1099 (4.502)

2014 SCI ADRM1 gene amplification is a candidate driver for metastatic gastric cancers.: Clinical & experimental metastasis. 31(6):727~733 (3.725)

2014 SCI Overexpression of miR-17 in gastric cancer is correlated with proliferation-associated oncogene amplification.: Pathology international. 64(7):309~314 (1.585)

2014 SCI MicroRNA signature for HER2-positive breast and gastric cancer.: Anticancer research. 34(7):3807~3810 (1.872)

2014 SCI A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma: Biomedical chromatography. 28(7):919~922 (1.662)

2014 SCI Low C24-OH and C22-OH sulfatides in human renal cell carcinoma: Journal of mass spectrometry : JMS. 49(5):409~16 (2.709)

2014 SCI miR-592 and miR-552 Can Distinguish Between Primary Lung Adenocarcinoma and Colorectal Cancer Metastases in the Lung: Anticancer research. 34(5):2297~2302 (1.872)

2014 SCI-E Preclinical Efficacy Testing for Stomach and Liver Cancers using a Hollow Fiber Assay: Cancer Research and Treatment. 46(2):186~193 (2.975)

2014 SCI A fully automated dual-online multifunctional ultrahigh pressure liquid chromatography system for high-throughput proteomics analysis: Journal of chromatography. A. 1329:83~89 (4.258)

2014 기타 Lipid MALDI MS profiles of gastric cancer: The Open Proteomics Journal. 7:1~4 (0)

2014 SCI Predictive biomarker candidates for the response of gastric cancer to targeted and cytotoxic agents: Pharmacogenomics. 15(3):375~384 (3.425)

2013 SCI Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.: Analytical and Bioanalytical Chemistry. 405(30):9817~9824 (3.659)

2013 SCI Lipid profiles for HER2-positive breast cancer: Anticancer Research. 33(6):2467~2472 (1.713)

2013 기타 MALDI MS Profiles Distinguish ER-Negative Breast Cancers from Lung Adenocarcinoma: Journal of Proteomics and Bioinformatics. 2013:S6~S6 (0)

2013 기타 Lipid MALDI MS Profiling Accurately Distinguishes Papillary Thyroid Carcinoma from Normal Tissue: Journal of Proteomics and Bioinformatics. 6:65~71 (0)

2013 SCI A label-free DC impedance-based microcytometer for circulating rare cancer cell counting: Lab on a Chip. 13(5):970~977 (5.697)

2012 SCI XAGE-1a and XAGE-1d are potential biomarkers of lung squamous cell carcinoma: Clinica Chemica Acta. 413:1226~1231 (2.535)

2012 SCI Lipid MALDI profile classifies non-small cell lung cancers according to the histologic type: Lung cancer. 76(2):197~203 (3.434)

2012 SCI Matrix-assisted laser desorption/ionization mass spectrometry reveals decreased calcylcin expression in small cell lung cancer: Pathology International. 62(1):28~35 (1.624)

2011 SCI TOFSIMS-P: A Web-Based Platform for Analysis of Large-Scale TOF-SIMS Data: analytical chemistry. 83:9298~9305 (5.874)

2011 SCI Alteration in lipid and protein profiles of ovarian cancer: similarity to breast cancer.: International Journal of Gynecological Cancer. 21(9):1566~1572 (1.558)

2011 SCI-E miRNA signature associated with outcome of gastric cancer patients following chemotherapy.: BMC Medical Genomics.. 4(1):e79~e79 (3.766)

2011 SCI-E Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype.: BMC cancer. 11:465~465 (3.153)

2011 SCI Lipid profiles for intrahepatic cholangiocarcinoma identified using matrix-assisted laser desorption/ionization mass spectrometry.: Clinica chimica acta. 412(21-22):1978~1982 (2.389)

2011 SCI Histology-directed matrix-assisted laser desorption/ionization analysis reveals tissue origin and p53 status of primary liver cancers: Pathology international. 61:449~455 (1.481)

2011 SCI-E Distinctions in gastric cancer gene expression signatures derived from laser capture microdissection versus histologic macrodissection.: BMC Medical Genomics. Online:Published (3.766)

2011 SCI-E A gene expression signature of acquired chemoresistance to Cisplatin and Fluorouracil combination chemotherapy in gastric cancer patients.: PLOS ONE. 6(2):e16694~e16694 (4.411)

2011 SCI Combined expression of miR-122a, miR-1, and miR-200b can differentiate degraded RNA samples from liver, pancreas, and stomach: Pathology international. 61(2):67~72 (1.481)

2010 SCI Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy: The Pharmacogenomics Journal. Online:Published (4.4)

2010 SCI Gastric cancer-specific protein profile identified using endoscopic biopsy samples via MALDI mass spectrometry.: Journal of proteome research. 9(8):4123~4130 (5.132)

2008 SCI Endoscopic ultrasound and computed tomography in restaging and predicting prognosis after neoadjuvant chemotherapy in patients with locally advanced gastric cancer.: Cancer. 112:2368~2376 (4.632)

2008 SCI Phase I/II study of S-1 combined with weekly docetaxel in patients with metastatic gastric carcinoma: British Journal of Cancer. 98:1305~11 (4.635)

2006 SCI Phase II study of docetaxel and irinotecan combination chemotherapy in metastatic gastric carcinoma: British Journal of Cancer. 94:1402~1406 (4.115)

2006 SCI Use of a combination of computed tomography and endoscopy to assess the response to 5-fluorouracil/cisplatin and predict survival in gastric cancer: Journal of Gastroenterology. 41:339~346 (1.532)

2006 SCI Assessment of lymph node metastases using 18F-FDG PET in patients with advanced gastric cancer: European Journal of Nuclear Medicine and Molecular Imaging. 33:148~155 (4.041)

2005 SCI Phase II Study of low-dose docetaxel/fluorouracil/cisplatin in metastatic gastric carcinoma: American Journal of Clinical Oncology. 28:433~438 (1.703)

2005 SCI Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers: Clinical Cancer Research. 11:3032~3037 (6.511)

2005 SCI Weekly Docetaxel in Combination With Capecitabine in Patients With Metastatic Gastric Cancer: American Journal of Clinical Oncology. 28:188~194 (1.703)

2004 SCI Incresed Expression of Metallothinonein Is Associated with Irinotecan Resistance in Gastric Cancer: Cancer Res. 64:4703~4706 (8.649)

2004 SCI DNA mociroarray analysis of the correlation between gene expression patterns and acquired resistance to 5-FU/cisplatin in gastric cancer: Biochemical and Biophysical Research Communications. 316:781~789 (2.904)

2004 SCI Decreased pyruvate kinase M2 activity linked to cisplatin resistance in human gastric carcinoma cell lines: INT J CANCER. 108:532~539 (4.056)

2004 SCI-E Weekly irinotecan in patients with metastatic gastric cancer failing cisplatin-based chemotherapy: Jpn J Clin Oncol. 34:8~13 (0.691)

2003 SCI Identification of genes with differential expression in acquired drug-resistant gastric cancer cells using high-density oligonucleotide microarrays: CLIN CANCER RES. 10:272~284 (5.991)

2003 SCI Development and applications of β-catenin oligonucleotide microarray : β-catenin mutations are dominantly found in the proximal cancers with microsatellite instalbilty: Clin Cancer Res. 9:2920~2925 (5.991)

2003 SCI Circulating numbers of endothelial progenitor cells in patients with gastric and breast cancer: Cancer Lett. 198:83~88 (1.741)

2003 SCI Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possilble role of a metastasis predictor: Eur J Cancer. 39:184~191 (3.46)

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