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Joo, Jung-Nam

Name
Joo, Jung Nam, Ph.D.(adjunct professor)
Faculty Appointment

Associate Professor, Department of Cancer Control and Population Health, NCC-GCSP
Area of Expertise
Statistical Genetics/Clinical Trials
Contact no
+82-31-920-1693
E-mail
jooj@ncc.re.kr
Previous Appointment(s) Held
Chief, Biometric Research Branch, National Cancer Center, Korea (Oct. 2010 - present)
Senior Scientist, Clinical Research Coordination Center, National Cancer Center, Korea (Oct. 2010 – present)
Mathematical Statistician (Biomedical), Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, USA (Aug. 2003 – Oct. 2010)
Educational Background
Ph. D. Applied Mathematics and Statistics, State University of New York (2003)
B.A. Computer Science and Statistics, Seoul National University (1998)
Research Interests
Dr. Joo ‘s statistical research has focused on developing analytic methodology for genetic association studies, and issues on analyzing large data set. She is particularly interested on robust statistical methodology for genetic studies which has higher power than conventional methods to seek for the true association. Additional research interests include design and monitoring of clinical trials, cancer epidemiology, survival analysis and design issues related to targeted therapy. Dr. Joo’s current collaborative interest lies on cancer research.
International Collaboration
Member, American Statistical Association
Member, Institute of Mathematical Statistics,
Member, Korean-American Scientist and Engineers Association
Member, Korean Statistical Society,
2017 SCI-E Retrospective analysis of 25 immunohistochemical tissue markers for differentiating multilocular cystic renal neoplasm of low malignant potential and multicystic renal cell carcinoma: Histology and histopathology. Online:Published (2.13)

2017 SCI Effect of biopsy site on detection of gastric cancer high-risk groups by OLGA and OLGIM stages: Helicobacter. 22(6):1~1 (3.429)

2017 SCI-E Reduced levels of N’-methyl-2-pyridone-5-carboxamide and lysophosphatidylcholine 16:0 in the serum of patients with intrahepatic cholangiocarcinoma, and the correlation with recurrence-free survival: Oncotarget. Online:Published (5.168)

2017 SCI-E A retrospective comparative study of progression-free survival and overall survival between metachronous and synchronous metastatic renal cell carcinoma in intermediate or poor risk patients treated with VEGF-targeted therapy: Oncotarget. 55:20674~20680 (5.168)

2017 SCI-E Retrograde pyelography predicts retrograde ureteral stenting failure and reduces unnecessary stenting trials in patients with advanced non-urological malignant ureteral obstruction: PLOS one. 12(9):e0184965~e0184965 (2.806)

2017 SCI-E Prognostic role of the Neutrophil-to-lymphocyte ratio in patients with Primary Central Nervous System Lymphoma: oncotarget. Online:Published (5.168)

2017 SCI-E Alpha-fetoprotein is a significant prognostic factor for gastric cancer:Results from a propensity score matching analysis after curative resection: European Journal of Surgical Oncology. 43(8):1542~1549 (3.522)

2017 SCI-E DCK expression, a potential predictive biomarker in the adjuvant gemcitabine chemotherapy for biliary tract cancer after surgical resection: results from a phase II study: oncotarget. Online:Published (5.168)

2017 SCI Integration Pattern of Human Papillomavirus Is a Strong Prognostic Factor for Disease-Free Survival After Radiation Therapy in Cervical Cancer Patients: International Journal of Radiation Oncology Biology Physics. 98(3):654~661 (5.133)

2017 SCI-E The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry: PLOS ONE. Online:Published (2.806)

2017 SCI-E Diagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis: Oncotarget. Online:Published (5.168)

2017 SCI-E Development and Evaluation of a Korean Version of a Thyroid Specific Quality-of-Life Questionnaire Scale in Thyroid Cancer Patient: Cancer Research And Treatment. Online:Published (3.772)

2017 SCI-E Effect of renal embolization in patients with synchronous metastatic renal cell carcinoma: A retrospective comparison of cytoreductive nephrectomy and systemic medical therapy: Oncotarget. Online:Published (5.168)

2017 SCI Comparison of the Abbott RealTime High Risk HPV test and the Roche cobas 4800 HPV test using urine samples: Journal of Virological Methods. 243:74~79 (1.693)

2017 SCI-E Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost-Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study: Cancer Research and Treatment. Online:Published (3.772)

2017 SCI-E Randomized phase II study of afatinib plus simvastatin versus afatinib alone in previously treated patients with advanced nonadenocarcinomatous Non-small Cell Lung Cancer: Cancer Research and Treatment. Online:Published (3.772)

2017 SCI Predictors of response to first-line immunosuppressive therapy in neuromyelitis optica spectrum disorders.: Multiple Sclerosis. Online:Published (4.84)

2016 SCI-E Post-mastectomy Radiotherapy in Patients with pT1-2N1 Breast Cancer Treated with Taxane-based Chemotherapy: A Retrospective Multicenter Analysis (KROG 1418).: Cancer Research and Treatment. Online:Published (4.245)

2016 SCI-E Development of the short version of the Gynecologic Cancer Lymphedema Questionnaire: GCLQ-7: Journal of Gynecologic Oncology. 28(2):e9~e9 (2.522)

2016 SCI-E Evaluation of the efficacy of solifenacin for preventing catheter-related bladder discomfort after transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer: a prospective, randomized, multicenter study .: clinical Genitourinary cancer. 15(1):157~162 (2.599)

2016 SCI Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer: Gut. 66(2):215~225 (14.921)

2016 SCI-E Efficacy of pancreatic exocrine replacement therapy for patients with unresectable pancreatic cancer in a randomized trial: Pancreatology. 16(6):1099~1105 (2.406)

2016 SCI Cognitive impairment differs between neuromyelitis optica spectrum disorder and multiple sclerosis.: Multiple Sclerosis Journal. 22(14):1850~1858 (4.671)

2016 SCI-E A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications.: Oncotarget. 7(47):77326~77341 (5.008)

2016 SCI Adjuvant radiotherapy for the treatment of stage IV rectal cancer after curative resection A propensity score-matched analysis and meta-analysis: Medicine. 95(47):e4925~e4925 (2.133)

2016 SCI-E Retrospective Analysis of Cerebrospinal Fluid Profiles in 228 Patients with Leptomeningeal Carcinomatosis : Differences According to the Sampling Site, Symptoms, and Systemic Factors.: Journal of Korean Neurosurgical Society. 59(6):570~576 (0.599)

2016 SCI-E Comparison of Quality of Life and Sexuality between Cervical Cancer Survivors and Healthy Women. Cancer Res Treat: Cancer research and treatment. 48(4):1321~1329 (4.245)

2016 SCI-E A retrospective study of predictive factors for unexpectedly prolonged or shortened progression-free survival and overall survival among patients with metastatic renal cell carcinoma who received first-line targeted therapy: BMC cancer. 16(1):577~577 (3.265)

2016 SCI-E Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer: PLoS One. 11(8):e0159424~e0159424 (3.057)

2016 SCI Different survival outcomes after curative R0-resection for Eastern Asian and European gastric cancer: Results from a propensity score matched analysis comparing a Korean and a German specialized center: Medicine (Baltimore). 95(28):e4261~e4261 (2.133)

2016 SCI-E Widespread cortical thinning in patients with neuromyelitis optica spectrum disorder.: European Journal of Neurology. 23(7):1165~1173 (3.956)

2016 SCI Intravoxel incoherent motion diffusion-weighted MR imaging of breast cancer: association with histopathological features and subtypes.: British Journal of Radiology. 89(1063):20160140~20160140 (1.84)

2016 SCI Comparison of DRY and WET vaginal swabs with cervical specimens in Roche Cobas 4800 HPV and Abbott RealTime High Risk HPV tests: Journal of Clinical Virology. 79:80~84 (2.647)

2016 SCI-E PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer: A retrospective study: Asian Journal of Andrology. Online:Published (2.644)

2016 SCI-E Prostate Stem Cell Antigen Expression in Radical Prostatectomy Specimens Predicts Early Biochemical Recurrence in Patients with High Risk Prostate Cancer Receiving Neoadjuvant Hormonal Therapy: PloS one. 11(3):e0151646~e0151646 (3.057)

2016 SCI Phase II randomized controlled trial of combined oral laxatives medication for bowel preparation (COMBO-PREP study): Medicine. 95(7):e2824~e2824 (2.133)

2016 SCI-E Development and Validation of a Prediction Model to Estimate Individual Risk of Pancreatic Cancer: PloS one. 11(1):e0146473~e0146473 (3.057)

2015 SCI-E Nucleotide Excision Repair Gene ERCC2 and 5 Variants Increase Risk of Uterine Cervical Cancer: Cancer Research and Treatment. 48(2):708~714 (3.318)

2015 SCI Overexpression of BRCA1 or BRCA2 in prostatectomy specimens is predictive of biochemical recurrence after radical prostatectomy: Histopathology. 68(5):673~679 (3.453)

2015 SCI Comparative analysis of treatment outcomes in patients with neuromyelitis optica spectrum disorder using multifaceted endpoints: Multiple sclerosis. 22(3):329~339 (4.822)

2015 SCI-E Percutaneous vertebroplasty for patients with metastatic compression fractures of the thoracolumbar spine: clinical and radiological factors affecting functional outcomes: The spine journal : official journal of the North American Spine Society. 16(3):355~364 (2.426)

2015 SCI-E Prognostic Implications of Tumor-Infiltrating Lymphocytes in Association With Programmed Death Ligand 1 Expression in Early-Stage Breast Cancer: Clinical Breast Cancer. 16(1):51~58 (2.107)

2015 SCI Assessment of Breast Cancer Patients’ Knowledge and Decisional Conflict Regarding Tamoxifen Use: Journal of Korean Medical Science. 30(11):1604~1611 (1.266)

2015 기타 The Efficacy of Postoperative Chemotherapy for Patients with Metastatic Brain Tumors from Non-Small Cell Lung Cancer.: Brain Tumor Research and Treatment. 3(2):108~114 (0)

2015 SCI Comparison of the performance of Anyplex II HPV HR, the Cobas 4800 human papillomavirus test and Hybrid Capture 2: Annals of clinical biochemistry. Online:Published (2.335)

2015 SCI-E The quantified level of circulating prostate stem cell antigen mRNA relative to GAPDH level is a clinically significant indictor for predicting biochemical recurrence in prostate cancer patients after radical prostatectomy: BioMed Research International. 2015:292454~292454 (1.579)

2015 SCI Impact of lower limb lymphedema on quality of life in gynecologic cancer survivors after pelvic lymph node dissection: European journal of obstetrics, gynecology, and reproductive biology. 192:31~36 (1.695)

2015 SCI Treatment Outcomes With Rituximab in 100 Patients With Neuromyelitis Optica: Influence of FCGR3A Polymorphisms on the Therapeutic Response to Rituximab: JAMA Neurology. 72(9):989~995 (7.271)

2015 SCI-E Robust Association Tests for the Replication of Genome-Wide Association Studies: BioMed Research International. 2015:461593~461593 (1.579)

2015 기타 Changing trends in colorectal cancer in the republic of Korea: contrast with Japan: Epidemiology and Health. Online:Published (0)

2015 SCI Trends in the Use of Chemotherapy Before and After Radical Cystectomy in Patients with Muscle-invasive Bladder Cancer in Korea: Journal of Korean medical science. 30(8):1150~1156 (1.266)

2015 SCI-E Prediction Model for Gastric Cancer Incidence in Korean Population: PloS one [electronic resource]. 10(7):0132613~0132613 (3.234)

2015 SCI A nomogram to predict brain metastasis as the first relapse in curatively resected non-small cell lung cancer patients: Lung cancer. 88(2):201~207 (3.958)

2015 SCI-E Individual having a parent with early-onset gastric cancer may need screening at younger age: World journal of gastroenterology. 21(15):4592~4598 (2.369)

2015 SCI-E Quality of life and sexuality comparison between sexually active ovarian cancer survivors and healthy women: Journal of gynecologic oncology. 26(2):148~154 (2.494)

2014 SCI The onset location of neuromyelitis optica spectrum disorder predicts the location of subsequent relapses.: Multiple sclerosis. 20(14):1908~1911 (4.863)

2014 SCI High Volumetric Breast Density Predicts Risk for Breast Cancer in Postmenopausal, but not Premenopausal, Korean Women: Annals of surgical oncology. 21(13):4124~4132 (3.943)

2014 SCI Estimated long-term dietary exposure to lead, cadmium, and mercury in young Korean children.: European Journal of Clinical Nutrition. 68(12):1322~1326 (2.95)

2014 SCI-E Ventriculolumbar Perfusion Chemotherapy With Methotrexate for Treating Leptomeningeal Carcinomatosis: A Phase II Study.: The oncologist. 19(10):1044~1045 (4.54)

2014 SCI-E A predictive model combining fecal calgranulin B and fecal occult blood tests can improve the diagnosis of colorectal cancer: PloS one. 9(9):e106182~e106182 (3.534)

2014 SCI Reply to questions in response to "improved survival after adding dissection of the superior mesenteric vein lymph node (14v) to standard D2 gastrectomy for advanced distal gastric cancer".: Surgery. 156(3):737~738 (3.105)

2014 SCI Development and validation of the korean version of the female sexual function index-6 (FSFI-6K): Yonsei medical journal. 55(5):1442~1446 (1.263)

2014 SCI-E A study of docetaxel and irinotecan in children and young adults with recurrent or refractory Ewing sarcoma family of tumors: BMC Cancer. 14:622~622 (3.319)

2014 SCI Genetic variations associated with postoperative recurrence in stage I non-small-cell lung cancer: Clinical Cancer Research. 20(12):3272~3279 (8.193)

2014 SCI Development and Evaluation of Korean Version of Quality of Sexual Function (QSF-K) in Healthy Korean Women: Journal of Korean Medical Science. 29(6):758~763 (1.253)

2014 SCI Development and evaluation of the Korean version of the Gynecologic Cancer Lymphedema Questionnaire in gynecologic cancer survivors: Gynecologic Oncology. 133(1):111~116 (3.687)

2014 SCI A Body Shape Index Has a Good Correlation with Postoperative Complications in Gastric Cancer Surgery: Annals of Surgical Oncology. 21(4):1115~1122 (3.943)

2014 SCI Randomized Clinical Trial Comparing Reduced-Volume Oral Picosulfate and a Prepackaged Low-Residue Diet With 4-Liter PEG Solution for Bowel Preparation: Diseases of the Colon & Rectum. 57(4):522~528 (3.198)

2014 SCI Comparison of Sentinel Lymph Node Biopsy Guided by the Multimodal Method of Indocyanine Green Fluorescence, Radioisotope, and Blue Dye Versus the Radioisotope Method in Breast Cancer: A Randomized Controlled Trial: Annals of Surgical Oncology. 21(4):1254~1259 (3.943)

2014 SCI Improved survival after adding dissection of the superior mesenteric vein lymph node (14v) to standard D2 gastrectomy for advanced distal gastric cancer: Surgery. 155(3):408~416 (3.105)

2014 SCI-E Risk prediction model for colorectal cancer: National Health Insurance Corporation study, Korea.: PLoS One. 9(2):e88079~e88079 (3.534)

2014 SCI-E Physical status of human papillomavirus integration in cervical cancer is associated with treatment outcome of the patients treated with radiotherapy: PLoS One. 9(1):e78995~e78995 (3.534)

2013 SCI-E Dosimetric Evaluation of Magnetic Resonance Imaging-based Intracavitary Brachytherapy for Cervical Cancer: Technology in Cancer Research and Treatment. 13(3):243~251 (1.886)

2013 SCI-E Validity of Korean Versions of the Multiple Sclerosis Impact Scale and the Multiple Sclerosis International Quality of Life Questionnaire: Journal of Clinical Neurology. 10(2):148~156 (1.807)

2013 SCI Difference in the phenotype, cytokine gene expression profiles and in vivo alloreactivity of T cells mobilized with plerixafor compared to G-CSF: Journal of Immunology. 191(12):6241~6249 (5.52)

2013 SCI Role of bursectomy for advanced gastric cancer: Result of a case-control study from a large volume hospital.: European Journal of Surgical Oncology. 39(12):1407~1414 (2.614)

2013 SCI Worse Outcome of Sorafenib Therapy Associated with Ascites and Child-Pugh Score in Advanced Hepatocellular Carcinoma1: Journal of Gastroenterology and Hepatology. 28(11):1756~1761 (3.325)

2013 SCI Rationale and design of the clarification of optimal anticoagulation through genetics trial: American Heart Journal. 166(3):435~441 (4.497)

2013 SCI Is there any role of additional retropancreatic lymph node dissection on D2 gastrectomy for advanced gastric cancer?: Annals Surgical Oncology. 20(8):2669~2675 (4.12)

2013 SCI Retrospective analysis of treatment outcome of pediatric ependymomas in Korea: analysis of Korean multi-institutional data.: Journal of Neuro-oncology. 113(1):39~48 (3.115)

2013 SCI Analysis of treatment outcomes of intraventricular chemotherapy in 105 patients for leptomeningeal carcinomatosis from non-small-cell lung cancer.: Journal of thoracic oncology. 8(5):599~605 (4.473)

2013 SCI-E The role of one-year endoscopic follow-up for the esophageal remnant and gastric conduit after esophagectomy with gastric reconstruction for esophageal squamous cell carcinoma.: Yonsei Medical Journal. 54(2):381~388 (1.306)

2013 SCI Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study: Carcinogenesis. 34(2):307~313 (5.632)

2013 SCI Risk of Pancreatic Cancer in Relation to ABO Blood Group and Hepatitis C Virus Infection in Korea: A Case-Control Study: Journal of Korean Medical Science. 28(2):247~251 (1.249)

2012 SCI-E Efficacy of intraoperative, single-bolus corticosteroid administration to prevent postoperative acute respiratory failure after esophageal cancer surgery: Interactive CardioVascular and Thoracic Surgery. 15(4):639~643 (0)

2012 SCI-E Incidence and risk factors for leptomeningeal carcinomatosis in breast cancer patients with parenchymal brain metastases: Journal of Korean Neurosurgical Society. 52(3):193~199 (0.604)

2012 기타 Mammographic density assessment by VolparaTM software as compared to visual BI-RADS classification: 대한유방검진의학회지. 9:127~132 (0)

2012 SCI Learning curve analysis of laparoscopic radical hysterectomy and lymph node dissection in early cervical cancer.: European journal of obstetrics, gynecology, and reproductive biology.. 163(2):219~223 (1.974)

2012 SCI Risk for leptomeningeal seeding after resection for brain metastases: implication of tumor location with mode of resection.: Journal of Neurosurgery. 116(5):984~993 (2.965)

2012 SCI Joint analysis of Binary and Quantitative traits with data sharing and outcome-dependent sampling: Genetic Epidemiology. 36(3):263~273 (3.441)

2012 SCI Wedge bronchoplastic lobectomy for non-small cell lung cancer as an alternative to sleeve lobectomy: The Journal of Thoracic and Cardiovascular Surgery. 143(4):825~831 (3.406)

2012 SCI Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer: International Journal of Gynecological Cancer. 22(2):267~272 (1.646)

2011 SCI Severity and Timing of Progression Predict Refractoriness to Transarterial Chemoembolization in Hepatocellular Carcinoma: J Gastroenterol Hepatol. 27(6):1051~1056 (2.865)

2011 SCI Chemoport with a non-collapsible chamber as a replacement for an Ommaya reservoir in the treatment of leptomeningeal carcinomatosis: Acta Neurochirugica. 153:1971~1978 (1.329)

2011 SCI-E Site-specific risk factors for colorectal cancer in a Korean population: PLoS ONE. 6:e23196~e23196 (4.411)

2011 SCI Simple Strategies for haplotype analysis of the X chromosome with application to age-related macular degeneration: European Journal of Human Genetics. 19:801~806 (4.38)

2011 SCI-E Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent restenosis.: BMC Medical Genomics. 4:20~30 (3.766)

2010 SCI-E Prospective alpha allocation in the Clarification of Optimal Anticoagulation through Genetics (COAG) trial: Clinical trials. 11:108~116 (1.917)

2010 SCI-E Prospective Alpha Allocation in the Clarification of Optimal Anticoagulation through Genetics (COAG) Trial.: Clinical Trials. 7:597~604 (1.917)

2010 SCI Improving Power for Testing Genetic Association in Case-Control Studies by Reducing Alternative Space.: Biometrics. 66:266~276 (1.867)

2010 SCI Tutorial in biostatistics: Efficiency robust statistics for genetic linkage and association studies under genetic model uncertainty.: Statistics in Medicine. 29:158~180 (1.99)

2010 SCI Robust Genome-Wide Scan Statistic of the Wellcome Trust Case-Control Consortium.: Biometrics. 65:1115~1122 (1.97)

2009 SCI A Robust Test for Two-Stage Design in Genome-Wide Association Studies.: Biometrics. 65:1288~12905 (1.97)

2009 SCI Robust tests in genome-wide scans under two-locus model.: Statistical Science. 24:503~516 (2.135)

2009 기타 Robust Genome-wide Scans with Genetic Model Selection using Case-Control Design.: Statistics and its interface. 2:133~144 ()

2009 SCI Conditional linkage and genome-wide association studies identify UGT1A1 as major gene for anti-athrogenic serum bilirubin levels - a Framingham Heart Study.: Atherosclerosis. 206:228~233 (4.601)

2009 SCI Steroid-Sparing Effects of Pentoxifylline in Pulmonary Sarcoidosis.: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 26:121~131 (1.267)

2009 SCI Pearsons test, trend test, and MAX are all trend tests with different types of scores.: Annals of Human Genetics. 73:133~140 (2.195)

2007 SCI Robust ranks of true ssociations in genome-wide case-control association studies: BMC Genetics. 1 (suppl1):165~167 (2.23)

2007 SCI Comparing strategies for evaluation of candidate genes in case-control studies using family data.: BMC Genetics. 1 (suppl1):32~34 (2.23)

2007 SCI Testing Association for Markers on the X chromosome.: Genetic Epidemiology. 31:834~843 (3.09)

2007 SCI Joint analysis of case-parents trio and unrelated case-control designs in large scale association studies.: BMC Genetics. 1 (suppl1):28~30 (2.23)

2005 SCI Robust trend tests for association in case-control studies using family data: BMC Genetics. 6 (suppl1):107~109 (2.23)

2005 SCI A new family-based association test via a least squares method.: BMC Genetics. 6 (suppl1):110~112 (2.23)

2005 SCI On averaging power for genetic association and linkage studies.: Human Heredity. 59:14~20 (3.806)

2005 SCI Selection of SNPs in disease association data.: BMC Genetics. 6 (suppl1):93~95 (2.23)

2004 SCI A Mixture-of-Genotypes Model for the distribution of thermostable phenol sulfotransferase activity.: Biometrical Journal. 46:707~719 (1.208)

2004 SCI Statistical approaches in the analysis of gene expression data derived from bone regeneration specific cDNA microarrays.: Journal of Biopharmaceutical Statistics. 4:607~628 (0.905)

2004 SCI Rational and study design of the CardioGene Study: genomics of in-stent restenosis.: Pharmacogenomics. 5:952~1004 (4.398)

2002 SCI Transcriptional Profiling of Bone Regeneration: Journal of Biological Chemistry. 277:30177~30182 (7.716)

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