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Park, Jong-Bae

Name
Park, Jong Bae, Ph.D.
Faculty Appointment
Professor & Dean, NCC-GCSP
Area of Expertise
Cell Biology/Tumor microenvironment
Contact no
+82-31-920-2720
E-mail
jbp@ncc.re.kr
Previous Appointment(s) Held
Post-doctoral fellow, Division of Neuroscience, Harvard medical school.
Department Chair, National Cancer Center Graduate School of Cancer Science and Policy
Educational Background
Ph.D. Life Science, POSTECH (2001)
M.S. Life Science, POSTECH (1998)
B.S. Gyeongsang National University (1994)
Research Interests
Dr. Park is an associate professor of system cancer science at GSCP. His research focuses on tumor microenvironment which is critical for the cancer stem cell proliferation and infiltration. He is also involved in several research projects on the development of anti-cancer drug targeting tumor microenvironment.
International Collaboration
Glioma stem cell invasion, Cleveland clinic (2010-present)
Induced glioma stem cell, Keio University (2012–present)
siRNA delivery, National Cancer Center, Japan (2009-present)
2017 SCI Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas: Cancer Letters. 414:181~189 (6.375)

2017 SCI The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing: Scientific reports. 7(1):13459~13459 (4.259)

2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. Online:Published (5.168)

2017 SCI Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBPβ signaling: Cancer Research. Online:Published (9.122)

2017 SCI Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.: Experimental & Molecular Medicine. 49(7):e351~e351 (5.063)

2017 SCI Preclinical development of a humanized neutralizing antibody targeting HGF: Experimental & Molecular Medicine. 49(3):e309~e309 (5.063)

2016 SCI-E TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling: Oncotarget. 7(48):79854~79868 (5.008)

2016 SCI Histone variant H3F3A promotes lung cancer cell migration through intronic regulation: Nature Communications. 7:12914~12914 (11.329)

2015 SCI DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis: Brain. 138(Pt9):2553~2570 (9.196)

2015 SCI Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells: PLoS biology. 13(5):1002152~1002152 (9.343)

2015 SCI Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes: Cell death and differentiation. 22(4):665~676 (8.184)

2015 SCI-E Radiation-induced autophagy contributes to cell death and induces apoptosis partly in malignant glioma cells.: Cancer research and treatment. 47(2):221~241 (3.318)

2015 SCI Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors: European journal of medicinal chemistry. 90:195~208 (3.447)

2014 SCI Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling.: Cancer letters. 353(2):194~200 (5.016)

2014 SCI-E CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression: Oncotarget. 5(16):6756~6769 (6.627)

2014 SCI Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression: Cancer research. 74(16):4482~4492 (9.284)

2014 SCI The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein: Biochimica et biophysica acta-Gene Regulatory Mechanisms. 1839(5):374~386 (5.44)

2014 기타 Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development: Brain tumor research and treatment. 2(1):1~6 (0)

2012 SCI Phospholipase signalling networks in cancer: Nature Reviews Cancer. 12(11):782~792 (37.545)

2012 SCI-E Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines.: PLOS ONE. 7(10):e47449~e47449 (4.092)

2012 SCI Hypoxia-induced up-regulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients: Oral Oncology. 48(6):500~506 (2.857)

2012 SCI Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling.: Brain. 135(4):1055~1069 (9.457)

2011 SCI-E PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1: PLoS ONE. 6(12):e28308~e28308 (4.411)

2011 SCI Human Brain Endothelial Cell-derived COX-2 Facilitates Extravasation of Breast Cancer Cells across the Blood-brain Barrier: Anticancer Research. 31(12):4307~4313 (1.656)

2011 SCI Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas: Oncogene. 30(21):2433~2442 (7.414)

2009 SCI Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling: Journal of Immunology. 183:7178~7186 (6)

2009 SCI HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress.: carcinogenesis. 30:1997~2004 (4.93)

2008 SCI 17-Allylamino-17-Demethoxygeldanamycin Down-Regulates Hyaluronic Acid-Induced Glioma Invasion by Blocking Matrix Metalloproteinase-9 Secretion: Molecular Cancer Research. 6:1657~1665 (4.317)

2008 SCI The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons: Journal of Biological Chemistry. 283:24690~24697 (5.581)

2006 SCI Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology: Nature. 442:814~817 (28.638)

2006 SCI The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis: Nature Cell Biology. 8:477~484 (17.623)

2005 SCI A TNF receptor family member TROY is a co-receptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors: Neuron. 45:345~351 (13.41)

2005 SCI EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans: Science. 310:106~110 (26.372)

2003 SCI Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition: Neuron. 38:177~185 (13.41)

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