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Park, Eun-Jung

Name
Park, Eun Jung, Ph.D.(full-time professor)
Faculty Appointment
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise

Inflammation, Immunotherapy, Tumor immunomicroenvironment, Neuroimmunology
Contact no
+82-31-920-2543, 2530
E-mail
ejpark@ncc.re.kr
Previous Appointment(s) Held
Chief, Cancer Immunology Branch (Immune and Cell Therapy Branch), National Cancer Center, Korea (2007-Present)
Chief, Immune and Cell Therapy Branch, National Cancer Center, Korea (2007-2012)
Visiting Scholar, Dept. of Biological Science, UCSD, USA (Sep. 2009 – Aug. 2010)
Director, GMP System Construction TF, National Cancer Center, Korea (Nov. 2007 – Aug. 2009)
Full-time Instructor, Ajou University School of Medicine, Korea(Sep. 2004 – Aug. 2006)
Educational Background
Ph. D. Molecular Biology, Seoul National University (1999)
MS Molecular Biology, Seoul National University (1993)
B.A. Biology, Ewha Womans University (1990)
Research Interests
Dr. Park’s primary research interests are in immune and inflammatory responses, especially pathological inflammatory responses and sterile inflammation. Her current research activities are mainly focused on the understanding of how inflammatory responses is set in motion and controlled, how we control the abnormal inflammation associated with diseases including cancer. Some latest research topics are tumor immunomicroenvironment and immunotherapy, TLRs in brain inflammation, oxidative stress and HIFs, and damage-associated endogenous molecules. She is now putting great emphasis on the crosstalk between cancer and immune cells and the interdependence of hypoxic stress and immune responses
International Collaboration
 
2017 SCI-E CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid: Oncology Letters. 13(4):2591~2598 (1.39)

2017 SCI Glatiramer acetate attenuates the activation of CD4+ T cells by modulating STAT1 and -3 signaling in glia: Scientific Reports. 7:40484~40484 (4.259)

2016 SCI-E nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer: Oncotarget. 7(46):75000~75012 (5.008)

2015 SCI Distinctive responses of brain tumor cells to TLR2 ligands:: Glia. 63(5):894~905 (6.031)

2015 SCI The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.: Nature communications [electronic resource]. 6:6340~6340 (11.47)

2015 SCI Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation.: Brain research bulletin. 112:25~34 (2.718)

2014 SCI-E EOP, a Newly Synthesized Ethyl Pyruvate Derivative, Attenuates the Production of Inflammatory Mediators via p38, ERK and NF-κB Pathways in Lipopolysaccharide-Activated BV-2 Microglial Cells.: Molecules. 19(12):19361~19375 (2.095)

2013 SCI-E Resveratrol Confers Protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells: PLos One. 8(4):e60654~60654 (3.73)

2013 SCI-E Regulation of microglia activity by glaucocalyxin-a: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-kB and p38 MAPK signaling pathways: PLos One. 8(2):e55792~e55792 (3.73)

2012 SCI Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necrotopsis: nature communications. 3:978~982 (7.396)

2011 SCI Dual Functionality of Myeloperoxidase in rotenone-exposed brain-resident immune cells: American Journal of Pathology. 179(2):964~979 (5.224)

2010 SCI Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway: Journal of Immunology. 185(11):7037~7046 (5.646)

2010 SCI Inflexin attenuates proinflammatory responses and nuclear factor kappa B activation in LPS-treated microglia: European Journal of Pharmacology. 633(1-3):98~106 (2.585)

2009 SCI Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T cells: Molecules and Cells. 28:533~558 (2.023)

2009 SCI-E Expression Profiling of Neuroinflammatory Genes in LPS and LPS/IFNgamma-stimulated BV2 microglia cells: Biochip Journal. 3:299~305 (0.65)

2009 SCI-E Genome-wide Inspection of Chromosomal Aberrations in Microglia BV-2 Cells by Array-based Comparative Genomic Hybridization: Biochip Journal. 3:28~36 (0.65)

2008 SCI Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells: Journal of Immunology. 181:8077~8087 (6.068)

2008 SCI Regulation of TLR2 expression by prostaglandins in brain glia.: Journal of Immunology. 180(12):8400~8409 (6.068)

2008 SCI Contribution of TLR2 to the initiation of ganglioside-triggered inflammatory signaling: Molecules and Cells. 25:99~104 (1.916)

2006 SCI Induction of microglial apoptosis by corticotropin-releasing hormone.: Journal of Neurochemistry. 98:962~972 (4.604)

2006 SCI Gangliosides trigger inflammatory responses via TLR4 in brain glia.: American Journal of Pathology. 168:1619~1630 (6.946)

2005 SCI Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells: Glia. 50:66~79 (4.781)

2004 SCI Rac1 Contributes to Maximal Activation of STAT1 and STAT3 in IFN--Stimulated Rat Astrocytes: Journal of Immunology. 2004:5697~5703 (6.702)

2003 SCI Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia: Journal of Immunology. 171:6072~6079 (6.702)

2003 SCI 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia: Journal of biological Chemistry. 278:14747~14752 (7.68)

2002 SCI A glucose-inducible gene in Schizosaccharomyces pombe, rrg1+, is involved in negative regulation of G2/M progression: Mol Cells. 14:312~317 (1.872)

2002 SCI JAK-STAT Signaling Mediates Gangliosides-induced Inflammatory Responses in Brain Microglial Cells: Journal of Biological Chemistry. 277:40594~40601 (7.68)

2002 SCI Interleukin-13 and -4 induce death of activated microglia: Glia. 38:273~280 (4.78)

2001 SCI Reactive oxygen species mediate A[beta](25-35)-induced activation of BV-2 microglia. Reactive oxygen species mediate A[beta](25-35)-induced activation of BV-2 microglia.: NeuroReport. 12:1449~1452 (2.7)

1999 SCI Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.: Nucleic Acid Research. 27:1524~1530 ()

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